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Giuseppe Paglietti
Researcher at University of Sassari
Publications - 125
Citations - 2198
Giuseppe Paglietti is an academic researcher from University of Sassari. The author has contributed to research in topics: Quinoxaline & Ring (chemistry). The author has an hindex of 24, co-authored 125 publications receiving 2016 citations.
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Chemistry, biological properties and SAR analysis of quinoxalinones.
TL;DR: These derivatives are reported to be potent no-NMDA glutamate receptor antagonists, endowed with anxiolytic, deconditioning, analgesic, antispastic, antiallergic, antithrombotic activities.
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Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives.
Michele Tonelli,Matteo Simone,Bruno Tasso,Federica Novelli,Vito Boido,Fabio Sparatore,Giuseppe Paglietti,Sabrina Pricl,Gabriele Giliberti,Sylvain Blois,Cristina Ibba,Giuseppina Sanna,Roberta Loddo,Paolo La Colla +13 more
TL;DR: The considered compounds represent attractive leads for the development of antiviral agents against poxviruses, pestiviruses and even HCV, which are important human and veterinary pathogens.
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Novel substituted quinoxaline 1,4-dioxides with in vitro antimycobacterial and anticandida activity
Antonio Carta,Giuseppe Paglietti,Mohammad E. Rahbar Nikookar,Paolo Sanna,Leonardo Antonio Sechi,Stefania Anna Lucia Zanetti +5 more
TL;DR: Thirty-six 6(7)-substituted-3-methyl- or 3-halogenomethyl-2-phenylthio-phenYLsulphonyl-chloro-quinoxaline 1,4-dioxides belonging to series 3-6 were synthesised and submitted to a preliminary in vitro evaluation for antimycobacterial, anticandida and antibacterial activities.
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Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
Antonio Cavazzuti,Giuseppe Paglietti,William N. Hunter,Francisco Gamarro,Sandra Piras,Mario Loriga,Sergio Allecca,Paola Corona,Karen McLuskey,Lindsay B. Tulloch,Federica Gibellini,Stefania Ferrari,Maria Paola Costi +12 more
TL;DR: The successful combination of antifolates targeting two enzymes indicates high potential for such an approach in the development of previously undescribed antiparasitic drugs.
Journal Article
Quinoxaline chemistry. Part 7. 2-[aminobenzoates]- and 2-[aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity.
TL;DR: In this paper, a series of quinoxalines bearing an aminobenzoyl (ABL) group on position 2 and various substituents on position 3,6,7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity.