Giuseppe Paglietti

TL;DR: These derivatives are reported to be potent no-NMDA glutamate receptor antagonists, endowed with anxiolytic, deconditioning, analgesic, antispastic, antiallergic, antithrombotic activities.

TL;DR: The considered compounds represent attractive leads for the development of antiviral agents against poxviruses, pestiviruses and even HCV, which are important human and veterinary pathogens.

TL;DR: Thirty-six 6(7)-substituted-3-methyl- or 3-halogenomethyl-2-phenylthio-phenYLsulphonyl-chloro-quinoxaline 1,4-dioxides belonging to series 3-6 were synthesised and submitted to a preliminary in vitro evaluation for antimycobacterial, anticandida and antibacterial activities.

TL;DR: The successful combination of antifolates targeting two enzymes indicates high potential for such an approach in the development of previously undescribed antiparasitic drugs.

TL;DR: In this paper, a series of quinoxalines bearing an aminobenzoyl (ABL) group on position 2 and various substituents on position 3,6,7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity.