Giuseppe Palermo

TL;DR: In blood and cerebrospinal fluid, mutant huntingtin (mHTT) and neurofilament light (NfL) protein concentrations correlated with disease severity in HD patients and showed that alterations in circulating NfL and mHTT concentrations may be among the earliest detectable changes in HD.

TL;DR: No SNPs associated with treatment response to TNF&agr; inhibitors are found in a genome-wide association study of 196 genetically homogenous Danish patients with RA and in a meta-analysis of available studies.

TL;DR: A complete disruption of TP53 function, either by a combination of point mutations and/or del17p, was associated with a high risk for disease progression and progression-free survival of patients with a heterozygous TP53 mutation was not significantly different from patients with an completely intact TP53 locus.

TL;DR: D dose-escalation designs that incorporate both the dose-limiting events and dose- Limiting toxicities (DLTs) and indicative responses of efficacy into the procedure are introduced.

TL;DR: Retrospective analysis from 2 independent trials revealed that increased PTK2 expression is associated with improved outcomes for CLL patients treated with R-FC vs FC, and may be a useful biomarker for patient selection in future trials.