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Amanda Heslegrave
Researcher at UCL Institute of Neurology
Publications - 150
Citations - 4232
Amanda Heslegrave is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 29, co-authored 107 publications receiving 2345 citations. Previous affiliations of Amanda Heslegrave include Hammersmith Hospital & Great Ormond Street Hospital.
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Journal ArticleDOI
Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease
Amanda Heslegrave,Wendy E. Heywood,Ross W. Paterson,Nadia K. Magdalinou,Johan Svensson,Per Johansson,Annika Öhrfelt,Kaj Blennow,John Hardy,Jonathan M. Schott,Kevin Mills,Henrik Zetterberg,Henrik Zetterberg +12 more
TL;DR: A mass spectrometry method using selected reaction monitoring for the presence of a TREM2 peptide is developed, which can be used to quantify levels of sTREM2 in CSF, and correlate with markers of neurodegeneration.
Journal ArticleDOI
G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
Roberto Simone,Rubika Balendra,Rubika Balendra,Thomas G. Moens,Thomas G. Moens,Elisavet Preza,Katherine M. Wilson,Amanda Heslegrave,Nathan S. Woodling,Teresa Niccoli,Javier Gilbert-Jaramillo,Samir Abdelkarim,Emma L. Clayton,Mica T. M. Clarke,Marie Therese Konrad,Andrew J. Nicoll,Jamie S. Mitchell,Andrea Calvo,Adriano Chiò,Henry Houlden,James M. Polke,Mohamed A. Ismail,Chad E. Stephens,Tam Vo,Abdelbasset A. Farahat,W. David Wilson,David W. Boykin,Henrik Zetterberg,Henrik Zetterberg,Linda Partridge,Linda Partridge,Selina Wray,Gary N. Parkinson,Stephen Neidle,Rickie Patani,Pietro Fratta,Adrian M. Isaacs +36 more
TL;DR: Data provide proof of principle that targeting GGGGCC repeat G‐quadruplexes has therapeutic potential and can ameliorate the two key pathologies associated with C9orf72 FTD/ALS.
Journal ArticleDOI
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Yuetiva Deming,Yuetiva Deming,Fabia Filipello,Francesca Cignarella,Claudia Cantoni,Simon Hsu,Robert J. Mikesell,Zeran Li,Jorge L. Del-Aguila,Umber Dube,Fabiana Geraldo Farias,Joseph Bradley,John P. Budde,Laura Ibanez,Maria Victoria Fernandez,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg,Amanda Heslegrave,Per Johansson,Johan Svensson,Bengt Nellgård,Alberto Lleó,Daniel Alcolea,Jordi Clarimón,Lorena Rami,Jose Luis Molinuevo,Marc Suárez-Calvet,Marc Suárez-Calvet,Estrella Morenas-Rodríguez,Gernot Kleinberger,Michael Ewers,Oscar Harari,Christian Haass,Christian Haass,Tom J. Brett,Bruno A. Benitez,Celeste M. Karch,Laura Piccio,Laura Piccio,Carlos Cruchaga +42 more
TL;DR: Two independent genetic associations in the membrane-spanning 4-domains subfamily A (MS4A) gene region suggest that MS4A4A modulates sTREM2 and indicate that TREM2 may be involved in AD pathogenesis not only in T REM2 risk-variant carriers but also in those with sporadic disease.
Journal ArticleDOI
Molecular biomarkers of Alzheimer's disease: progress and prospects.
Tammaryn Lashley,Jonathan M. Schott,Philip S.J. Weston,CE Murray,Henny Wellington,Ashvini Keshavan,Sandrine C. Foti,Martha S. Foiani,Jamie Toombs,Jonathan D. Rohrer,Amanda Heslegrave,Henrik Zetterberg +11 more
TL;DR: This ‘At a glance’ article summarises the molecular biomarkers that are being developed to detect Alzheimer's disease and its related pathologies, highlighting the challenges and opportunities for diagnostic and prognostic applications.
Journal ArticleDOI
Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease
Lauren M. Byrne,Filipe B. Rodrigues,Eileanoir B. Johnson,P. A. Wijeratne,Enrico De Vita,Daniel C. Alexander,Giuseppe Palermo,Christian Czech,Scott Schobel,Rachael I. Scahill,Amanda Heslegrave,Henrik Zetterberg,Edward J. Wild +12 more
TL;DR: In blood and cerebrospinal fluid, mutant huntingtin (mHTT) and neurofilament light (NfL) protein concentrations correlated with disease severity in HD patients and showed that alterations in circulating NfL and mHTT concentrations may be among the earliest detectable changes in HD.