R
Riyue Bao
Researcher at University of Pittsburgh
Publications - 104
Citations - 8922
Riyue Bao is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Tumor microenvironment & Cancer. The author has an hindex of 26, co-authored 88 publications receiving 6379 citations. Previous affiliations of Riyue Bao include University of Chicago & Wayne State University.
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Journal ArticleDOI
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
TL;DR: The mechanism by which tumour-intrinsic active β-catenin signalling results in T-cell exclusion and resistance to anti-PD-L1/anti-CTLA-4 monoclonal antibody therapy is identified, pointing to new candidate targets for immune potentiation.
Journal ArticleDOI
The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients
Vyara Matson,Jessica Fessler,Riyue Bao,Tara Chongsuwat,Yuanyuan Zha,Maria-Luisa Alegre,Jason J. Luke,Thomas F. Gajewski +7 more
TL;DR: The results suggest that the commensal microbiome may have a mechanistic impact on antitumor immunity in human cancer patients and could lead to improved tumor control, augmented T cell responses, and greater efficacy of anti–PD-L1 therapy.
Journal ArticleDOI
The genome of the model beetle and pest Tribolium castaneum.
Stephen Richards,Richard A. Gibbs,George M. Weinstock,Susan J. Brown,Robin Denell,Richard W. Beeman,R. A. Gibbs,Gregor Bucher,Markus Friedrich,Cornelis J. P. Grimmelikhuijzen,Martin Klingler,Marcé D. Lorenzen,Siegfried Roth,Reinhard Schröder,Diethard Tautz,Evgeny M. Zdobnov,Donna M. Muzny,Tony Attaway,Stephanie Bell,Christian J. Buhay,Mimi N. Chandrabose,Dean Chavez,Kerstin P. Clerk-Blankenburg,Andrew Cree,Marvin Diep Dao,Clay Davis,Joseph Chacko,Huyen Dinh,Shannon Dugan-Rocha,Gerald R. Fowler,Toni T. Garner,Jeffrey Garnes,Andreas Gnirke,Alica Hawes,Judith Hernandez,Sandra Hines,Michael Holder,Jennifer Hume,Shalini N. Jhangiani,Vandita Joshi,Ziad Khan,LaRonda Jackson,Christie Kovar,Andrea Kowis,Sandra L. Lee,Lora Lewis,Jon Margolis,Margaret Morgan,Lynne V. Nazareth,Ngoc Nguyen,Geoffrey Okwuonu,David A. Parker,San Juana Ruiz,Jireh Santibanez,Joël Savard,Steven E. Scherer,Brian W. Schneider,Erica Sodergren,Selina Vattahil,Donna Villasana,Courtney Sherell White,Rita A. Wright,Yoonseong Park,Jeff Lord,Brenda Oppert,Susan J Brown,Liangjiang Wang,George Weinstock,Yue Liu,Kim C. Worley,Christine G. Elsik,Justin T. Reese,Eran Elhaik,Giddy Landan,Dan Graur,Peter Arensburger,Peter W. Atkinson,Jim Beidler,Jeffery P. Demuth,Douglas W. Drury,Yu Zhou Du,Haruhiko Fujiwara,Vincenza Maselli,Mizuko Osanai,Hugh M. Robertson,Zhijian Tu,Jianjun Wang,Suzhi Wang,Henry Song,Lan Zhang,Doreen Werner,Mario Stanke,Burkhard Morgenstern,Victor V. Solovyev,Peter Kosarev,Garth Brown,Hsiu Chuan Chen,Olga Ermolaeva,Wratko Hlavina,Yuri Kapustin,Boris Kiryutin,Paul Kitts,Donna Maglott,Kim D. Pruitt,Victor Sapojnikov,Alexandre Souvorov,Aaron J. Mackey,Robert M. Waterhouse,Stefan Wyder,Evgenia V. Kriventseva,Tatsuhiko Kadowaki,Peer Bork,Manuel Aranda,Riyue Bao,Anke Beermann,Nicola Berns,Renata Bolognesi,François Bonneton,Daniel Bopp,Thomas Butts,Arnaud Chaumot,Robin E. Denell,David E. K. Ferrier,Cassondra M. Gordon,Marek Jindra,Que Lan,H. Michael G. Lattorff,Vincent Laudet,Cornelia Von Levetsow,Zhenyi Liu,Rebekka Lutz,Jeremy A. Lynch,Rodrigo Nunes da Fonseca,Nico Posnien,Rolf Reuter,Johannes B. Schinko,Christian Schmitt,Michael Schoppmeier,Teresa D. Shippy,Franck Simonnet,Henrique Marques-Souza,Yoshinori Tomoyasu,Jochen Trauner,Maurijn van der Zee,Michel Vervoort,Nadine Wittkopp,Ernst A. Wimmer,Xiaoyun Yang,Andrew K. Jones,David B. Sattelle,Paul R. Ebert,David R. Nelson,Jeffrey G. Scott,Subbaratnam Muthukrishnan,Karl J. Kramer,Yasuyuki Arakane,Qingsong Zhu,David G. Hogenkamp,Radhika Dixit,Haobo Jiang,Zhen Zou,Jeremy L. Marshall,Elena N. Elpidina,K.S. Vinokurov,Cris Oppert,Jay D. Evans,Zhiqiang Lu,Picheng Zhao,Niranji Sumathipala,Boran Altincicek,Andreas Vilcinskas,Michael Williams,Dan Hultmark,Charles Hetru,Frank Hauser,Giuseppe Cazzamali,Michael Williamson,Bin Li,Yoshiaki Tanaka,Reinhard Predel,Susanne Neupert,Joachim Schachtner,Peter Verleyen,Florian Raible,Kimberly K. O. Walden,Sergio Angeli,Sylvain Forêt,Stefan Schuetz,Ryszard Maleszka,Sherry Miller,Daniela Grossmann +190 more
TL;DR: Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products.
Journal ArticleDOI
WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers
TL;DR: Activation of tumor-intrinsic WNT/β-catenin signaling is enriched in non-T-cell-inflamed tumors, providing a strong rationale for developing pharmacologic inhibitors of this pathway with the aim of restoring immune cell infiltration and augmenting immunotherapy.
Journal ArticleDOI
Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma.
Stefani Spranger,Jason J. Luke,Riyue Bao,Yuanyuan Zha,Kyle M. Hernandez,Yan Li,Alexander P Gajewski,Jorge Andrade,Thomas F. Gajewski +8 more
TL;DR: The results indicate that lack of spontaneous immune infiltration in solid tumors is unlikely to be due to lack of antigens, and strategies that improve T-cell infiltration into tumors may therefore be able to facilitate clinical response to immunotherapy once antIGens become recognized.