G
Gommaar D'Hulst
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 14
Citations - 1706
Gommaar D'Hulst is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Leucine & Skeletal muscle. The author has an hindex of 4, co-authored 13 publications receiving 936 citations. Previous affiliations of Gommaar D'Hulst include Katholieke Universiteit Leuven & ETH Zurich.
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Journal ArticleDOI
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.
Gommaar D'Hulst,Inés Soro-Arnaiz,Evi Masschelein,Koen Veys,Gillian Fitzgerald,Benoit Smeuninx,Sunghoon Kim,Louise Deldicque,Bert Blaauw,Peter Carmeliet,Leigh Breen,Peppi Koivunen,Shimin Zhao,Shimin Zhao,Katrien De Bock +14 more
TL;DR: The authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner and prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucines.
Journal ArticleDOI
Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization
Jing Zhang,Jonathan Muri,Gillian Fitzgerald,Tatiane Gorski,Roberto Gianni-Barrera,Evi Masschelein,Gommaar D'Hulst,Paola Gilardoni,Guillermo Turiel,Zheng Fan,TongTong Wang,Mélanie Planque,Peter Carmeliet,Luc Pellerin,Luc Pellerin,Christian Wolfrum,Sarah-Maria Fendt,Andrea Banfi,Christian Stockmann,Inés Soro-Arnaiz,Manfred Kopf,Katrien De Bock +21 more
TL;DR: ECs exploit glycolysis for angiocrine lactate shuttling to steer muscle regeneration from ischemia and rescue macrophage polarization and improved muscle reperfusion and regeneration.
Journal ArticleDOI
Exercise promotes satellite cell contribution to myofibers in a load-dependent manner
Evi Masschelein,Gommaar D'Hulst,Joel Zvick,Laura Hinte,Inés Soro-Arnaiz,Tatiane Gorski,Ferdinand von Meyenn,Ori Bar-Nur,Katrien De Bock +8 more
TL;DR: By performing fate tracing at the DNA level, it is shown that SC contribution mirrors myonuclear accretion during exercise, and mechanical load during exercise independently promotes SC contribution to existing myofibers.
Posted ContentDOI
Exercise promotes satellite cell contribution to myofibers in a load-dependent manner
Evi Masschelein,Gommaar D'Hulst,Joel Zvick,Laura Hinte,Inés Soro-Arnaiz,Tatiane Gorski,Ferdinand von Meyenn,Ori Bar-Nur,Katrien De Bock +8 more
TL;DR: By performing fate tracing at the DNA level, it is shown that SC contribution mirrors myonuclear accretion during exercise, providing direct evidence that mechanical load during exercise independently promotes SC contribution to existing myofibers.
Journal ArticleDOI
Voluntary Resistance Running as a Model to Induce mTOR Activation in Mouse Skeletal Muscle.
TL;DR: Voluntary resistance running is shown to be an easy-to-use, time-efficient and low stress model to study acute alterations in mTORC1 signaling upon high-load muscular contractions in mice.