G
Gracia María Martín-Núñez
Researcher at Carlos III Health Institute
Publications - 20
Citations - 561
Gracia María Martín-Núñez is an academic researcher from Carlos III Health Institute. The author has contributed to research in topics: Insulin resistance & Population. The author has an hindex of 11, co-authored 19 publications receiving 447 citations.
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Journal ArticleDOI
Neonatal Androgen Exposure Causes Persistent Gut Microbiota Dysbiosis Related to Metabolic Disease in Adult Female Rats
Isabel Moreno-Indias,Lidia Sánchez-Alcoholado,Miguel Ángel Sánchez-Garrido,Gracia María Martín-Núñez,Francisco Pérez-Jiménez,Francisco Pérez-Jiménez,Francisco Pérez-Jiménez,Manuel Tena-Sempere,Manuel Tena-Sempere,Francisco J. Tinahones,María Isabel Queipo-Ortuño +10 more
TL;DR: The data are the first to document the durable impact of sex steroid manipulations, and particularly early androgenization, on gut microbiota composition, and such dysbiosis is likely to contribute to the metabolic perturbations of conditions of obesity linked to gonadal dysfunction in the female.
Journal ArticleDOI
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
Geoffrey A. Walford,Stefan Gustafsson,Denis Rybin,Alena Stančáková,Han Chen,Han Chen,Ching-Ti Liu,Jaeyoung Hong,Richard A. Jensen,Kenneth Rice,Andrew P. Morris,Andrew P. Morris,Reedik Mägi,Anke Tönjes,Inga Prokopenko,Inga Prokopenko,Marcus E. Kleber,Graciela E. Delgado,Günther Silbernagel,Anne U. Jackson,Emil V. R. Appel,Niels Grarup,Joshua P. Lewis,May E. Montasser,Claes Landenvall,Claes Landenvall,Harald Staiger,Jian'an Luan,Timothy M. Frayling,Michael N. Weedon,Weijia Xie,Sonsoles Morcillo,María Teresa Martínez-Larrad,Mary L. Biggs,Yii-Der Ida Chen,Arturo Corbatón-Anchuelo,Kristine Færch,J M Gómez-Zumaquero,Mark O. Goodarzi,Jorge R. Kizer,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Aaron Leong,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Fausto Machicao,Alisa K. Manning,Gracia María Martín-Núñez,Gemma Rojo-Martínez,Jerome I. Rotter,David S. Siscovick,David S. Siscovick,Joseph M. Zmuda,Zhongyang Zhang,Manuel Serrano-Ríos,Ulf Smith,Federico Soriguer,Torben Hansen,Torben Jørgensen,Torben Jørgensen,Allan Linnenberg,Oluf Pedersen,Mark Walker,Claudia Langenberg,Robert A. Scott,Nicholas J. Wareham,Andreas Fritsche,Hans-Ulrich Häring,Norbert Stefan,Leif Groop,Leif Groop,Jeffrey R. O'Connell,Michael Boehnke,Richard N. Bergman,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Winfried März,Winfried März,Winfried März,Peter Kovacs,Michael Stumvoll,Bruce M. Psaty,Bruce M. Psaty,Johanna Kuusisto,Markku Laakso,James B. Meigs,Josée Dupuis,Josée Dupuis,Erik Ingelsson,Erik Ingelsson,Jose C. Florez +93 more
TL;DR: A genome-wide association study of the modified Stumvoll Insulin Sensitivity Index (ISI) was performed within the Meta-Analyses of Glucose and Insulin-Related Traits Consortium, identifying two novel loci and replicated known variants associated with insulin sensitivity.
Journal ArticleDOI
Type 2 diabetes mellitus in relation to global LINE-1 DNA methylation in peripheral blood: A cohort study
Gracia María Martín-Núñez,Elehazara Rubio-Martín,Rebeca Cabrera-Mulero,Gemma Rojo-Martínez,Gabriel Olveira,Sergio Valdés,Federico Soriguer,Luis Castaño,Sonsoles Morcillo +8 more
TL;DR: Lower LINE-1 DNA methylation levels were associated with a higher risk metabolic status worsening, independent of other classic risk factors, highlighting the potential role for epigenetic biomarkers as predictors of T2DM risk or other related metabolic disorders.
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
Geoffrey A. Walford,Stefan Gustafsson,Denis Rybin,Alena Stančáková,Han Chen,Ching-Ti Liu,Jaeyoung Hong,Richard A. Jensen,Kenneth Rice,Andrew P. Morris,Reedik Mägi,Anke Toenjes,Inga Prokopenko,Marcus E. Kleber,Graciela E. Delgado,Guenther Silbernagel,Anne U. Jackson,Emil V. R. Appel,Niels Grarup,Joshua P. Lewis,May E. Montasser,Claes Landenvall,Harald Staiger,Jian'an Luan,Timothy M. Frayling,Michael N. Weedon,Weijia Xie,Sonsoles Morcillo,María Teresa Martínez-Larrad,Mary L. Biggs,Yii-Der Ida Chen,Arturo Corbatón-Anchuelo,Kristine Færch,J M Gómez-Zumaquero,Mark O. Goodarzi,Jorge R. Kizer,Heikki A. Koistinen,Aaron Leong,Lars Lind,Cecilia M. Lindgren,Fausto Machicao,Alisa K. Manning,Gracia María Martín-Núñez,Gemma Rojo-Martínez,Jerome I. Rotter,David S. Siscovick,Joseph M. Zmuda,Zhongyang Zhang,Manuel Serrano-Ríos,Ulf Smith,Federico Soriguer,Torben Hansen,Torben Jørgensen,Allan Linnenberg,Oluf Pedersen,Mark Walker,Claudia Langenberg,Robert A. Scott,Nicholas J. Wareham,Andreas Fritsche,Hans-Ulrich Haering,Norbert Stefan,Leif Groop,Jeffrey R. O'Connell,Michael Boehnke,Richard N. Bergman,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Winfried Maerz,Peter Kovacs,Michael Stumvoll,Bruce M. Psaty,Johanna Kuusisto,Markku Laakso,James B. Meigs,Josée Dupuis,Erik Ingelsson,Jose C. Florez +78 more
TL;DR: This article performed a GWAS of the modified Stumvoll insulin sensitivity index (ISI) within the Meta-Analyses of Glucose and Insulin-Related Traits Consortium.
Journal ArticleDOI
Plasma selenium levels and oxidative stress biomarkers: a gene-environment interaction population-based study.
Inmaculada Galan-Chilet,Maria Tellez-Plaza,Eliseo Guallar,Griselda de Marco,Raúl López-Izquierdo,Isabel Gonzalez-Manzano,M. Carmen Tormos,Gracia María Martín-Núñez,Gemma Rojo-Martínez,Guillermo T. Sáez,Juan Carlos Martín-Escudero,Josep Redon,F. Javier Chaves +12 more
TL;DR: It is found that high selenium levels increase oxidative stress in some biological processes, and potential risk genotypes associated with increased levels of oxidative stress markers with high seenium levels are identified.