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Gregg E. Homanics
Researcher at University of Pittsburgh
Publications - 211
Citations - 12575
Gregg E. Homanics is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: GABAA receptor & Receptor. The author has an hindex of 61, co-authored 204 publications receiving 11632 citations. Previous affiliations of Gregg E. Homanics include University of North Carolina at Chapel Hill & Stanford University.
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Journal ArticleDOI
Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice
Robert M. Mihalek,Pradeep K. Banerjee,Esa R. Korpi,Joseph J. Quinlan,Leonard L. Firestone,Zhi Ping Mi,Carl F. Lagenaur,Verena Tretter,Werner Sieghart,Stephan G. Anagnostaras,Jennifer R. Sage,Michael S. Fanselow,Alessandro Guidotti,Igor Spigelman,Zhiwei Li,Timothy M. DeLorey,Richard W. Olsen,Gregg E. Homanics +17 more
TL;DR: The results begin to illuminate the novel contributions of the delta subunit to GABA pharmacology and sedative/hypnotic responses and behavior and provide insights into the physiology of neurosteroids.
Journal ArticleDOI
Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior
Gregg E. Homanics,Timothy M. DeLorey,Leonard L. Firestone,Joseph J. Quinlan,Adrian Handforth,Neil L. Harrison,Matthew D. Krasowski,Caroline E. Rick,Esa R. Korpi,Esa R. Korpi,Riikka Mäkelä,Riikka Mäkelä,Murray H. Brilliant,Nobuko Hagiwara,Carolyn Ferguson,Kimberly Snyder,Richard W. Olsen +16 more
TL;DR: Hyperactivity, lack of coordination, and seizures in β3-deficient mice are consistent with reduced presynaptic inhibition in spinal cord and impaired inhibition in higher cortical centers and/or pleiotropic developmental defects.
Journal ArticleDOI
Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome.
Timothy M. DeLorey,Adrian Handforth,Stephan G. Anagnostaras,Gregg E. Homanics,B. A. Minassian,A. Asatourian,Michael S. Fanselow,Antonio V. Delgado-Escueta,G. D. Ellison,Richard W. Olsen +9 more
TL;DR: The loss of the single gene, gabrb3, in these mice is sufficient to cause phenotypic traits that have marked similarities to the clinical features of AS, indicating that impaired expression of the GABRB3 gene in humans probably contributes to the overall phenotype of Angelman syndrome.
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Reciprocal Inhibitory Connections and Network Synchrony in the Mammalian Thalamus
Molly M. Huntsman,Darrell M. Porcello,Gregg E. Homanics,Timothy M. DeLorey,John R. Huguenard +4 more
TL;DR: In beta3 knockout mice, GABAA-mediated inhibition was nearly abolished in reticular nucleus, but was unaffected in relay cells, and oscillatory synchrony was dramatically intensified, suggesting that recurrent inhibitory connections within reticle nucleus act as "desynchronizers."
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Inhaled anesthetics and immobility: Mechanisms, mysteries, and minimum alveolar anesthetic concentration
James M. Sonner,Joseph F. Antognini,Robert C. Dutton,Pamela Flood,Andrew T. Gray,R. Adron Harris,Gregg E. Homanics,Joan J. Kendig,Beverley A. Orser,Douglas E. Raines,James R. Trudell,Bryce Vissel,Edmond I. Eger +12 more
TL;DR: Understanding of where and how inhaled anesthetics act to produce immobility by actions on the spinal cord is advanced, but in vivo studies to date suggest that several channels or receptors may not be mediators.