L
Leonard L. Firestone
Researcher at University of Pittsburgh
Publications - 73
Citations - 4520
Leonard L. Firestone is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: GABAA receptor & Receptor. The author has an hindex of 32, co-authored 73 publications receiving 4383 citations. Previous affiliations of Leonard L. Firestone include Harvard University & Boston Children's Hospital.
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Journal ArticleDOI
Pain processing during three levels of noxious stimulation produces differential patterns of central activity.
Stuart W. G. Derbyshire,Anthony K. P. Jones,Ferenc E. Gyulai,Stuart Clark,David W. Townsend,Leonard L. Firestone +5 more
TL;DR: Comparisons and correlation analysis indicated a wide range of active regions including bilateral prefrontal, inferior parietal and premotor cortices and thalamic responses, contralateral hippocampus, insula and primary somatosensory cortex and ipsilateral perigenual cingulate cortex and medial frontal cortex.
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Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice
Robert M. Mihalek,Pradeep K. Banerjee,Esa R. Korpi,Joseph J. Quinlan,Leonard L. Firestone,Zhi Ping Mi,Carl F. Lagenaur,Verena Tretter,Werner Sieghart,Stephan G. Anagnostaras,Jennifer R. Sage,Michael S. Fanselow,Alessandro Guidotti,Igor Spigelman,Zhiwei Li,Timothy M. DeLorey,Richard W. Olsen,Gregg E. Homanics +17 more
TL;DR: The results begin to illuminate the novel contributions of the delta subunit to GABA pharmacology and sedative/hypnotic responses and behavior and provide insights into the physiology of neurosteroids.
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Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior
Gregg E. Homanics,Timothy M. DeLorey,Leonard L. Firestone,Joseph J. Quinlan,Adrian Handforth,Neil L. Harrison,Matthew D. Krasowski,Caroline E. Rick,Esa R. Korpi,Esa R. Korpi,Riikka Mäkelä,Riikka Mäkelä,Murray H. Brilliant,Nobuko Hagiwara,Carolyn Ferguson,Kimberly Snyder,Richard W. Olsen +16 more
TL;DR: Hyperactivity, lack of coordination, and seizures in β3-deficient mice are consistent with reduced presynaptic inhibition in spinal cord and impaired inhibition in higher cortical centers and/or pleiotropic developmental defects.
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Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics.
Gregg E. Homanics,Carolyn Ferguson,Joseph J. Quinlan,Jodi Daggett,Kimberly Snyder,Carl F. Lagenaur,Zhi-Ping Mi,Xiao-Hui Wang,Dennis R. Grayson,Leonard L. Firestone +9 more
TL;DR: The a6 subunit of the GABAA-R is not required for normal development, viability, and fertility and does not seem to be a critical or unique component of the neuronal pathway mediating the hypnotic effect of ethanol and its antagonism by Ro15‐ 4513 in mice.
Journal ArticleDOI
Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study.
Daniel B. Carr,Leonidas C. Goudas,William T. Denman,Daniel Brookoff,Peter S. Staats,Loralie M. Brennen,Geoff A. Green,Randi Albin,Douglas A. Hamilton,Mark C Rogers,Leonard L. Firestone,Philip T Lavin,Fred Mermelstein +12 more
TL;DR: Intranasal administration of ketamine provides rapid, safe and effective relief for BTP, with pain relief within 10 min of dosing and lasting for up to 60 min.