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Igor Spigelman
Researcher at University of California, Los Angeles
Publications - 89
Citations - 5874
Igor Spigelman is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: GABAA receptor & Dentate gyrus. The author has an hindex of 39, co-authored 84 publications receiving 5477 citations. Previous affiliations of Igor Spigelman include University of Toronto & Toronto Western Hospital.
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Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice
Robert M. Mihalek,Pradeep K. Banerjee,Esa R. Korpi,Joseph J. Quinlan,Leonard L. Firestone,Zhi Ping Mi,Carl F. Lagenaur,Verena Tretter,Werner Sieghart,Stephan G. Anagnostaras,Jennifer R. Sage,Michael S. Fanselow,Alessandro Guidotti,Igor Spigelman,Zhiwei Li,Timothy M. DeLorey,Richard W. Olsen,Gregg E. Homanics +17 more
TL;DR: The results begin to illuminate the novel contributions of the delta subunit to GABA pharmacology and sedative/hypnotic responses and behavior and provide insights into the physiology of neurosteroids.
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Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors.
TL;DR: Data suggest that specific alterations in GABAR occur after CIE and may underlie the development of hyperexcitability and ethanol dependence.
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GABAA receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol
Dev Chandra,F. Jia,J. Liang,Z. Peng,Asha Suryanarayanan,David F. Werner,Igor Spigelman,Carolyn R. Houser,Richard W. Olsen,Neil L. Harrison,Gregg E. Homanics +10 more
TL;DR: It is demonstrated that tonic inhibition in dentate granule cells and thalamic relay neurons is mediated by extrasynaptic GABAA-Rs containing the α4 subunit and that gaboxadol achieves its effects via the activation of this GabAA-R subtype.
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Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry.
TL;DR: The results indicate that HBDs are present in the pilocarpine model of temporal lobe epilepsy, confirm the presence of H BDs in the kainate model, and show that Hbds are postsynaptic to mossy fibers.
Journal ArticleDOI
Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo
Michael Tymianski,M. Christopher Wallace,Igor Spigelman,Masaaki Uno,Peter L. Carlen,Charles H. Tator,Milton P. Charlton +6 more
TL;DR: This report provides the most direct evidence to date that intracellular Ca2+ excess triggers early neurodegeneration in vivo and contributes a novel therapeutic approach to neuronal ischemia of potential clinical utility.