G
Gretchen L. Kiser
Researcher at Amersham plc
Publications - 18
Citations - 1853
Gretchen L. Kiser is an academic researcher from Amersham plc. The author has contributed to research in topics: Gene & Substantia nigra. The author has an hindex of 15, co-authored 18 publications receiving 1794 citations. Previous affiliations of Gretchen L. Kiser include California Institute of Technology & GE Healthcare.
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Journal ArticleDOI
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.
TL;DR: It is concluded that the checkpoint in budding yeast consists of overlapping S-phase and G2-phase pathways that respond to incomplete DNA replication and/or DNA damage and cause arret of cells before mitosis.
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The External RNA Controls Consortium: a progress report.
Shawn C. Baker,Steven R. Bauer,Richard P. Beyer,James D. Brenton,Bud Bromley,John Burrill,Helen C. Causton,Michael P Conley,Rosalie K. Elespuru,Michael J. Fero,Carole Foy,James C. Fuscoe,Xiaolian Gao,David Gerhold,Patrick Gilles,Federico Goodsaid,Xu Guo,Joe Hackett,Richard D. Hockett,Pranvera Ikonomi,Rafael A. Irizarry,Ernest S. Kawasaki,Tamma Kaysser-Kranich,Kathleen F. Kerr,Gretchen L. Kiser,Walter H. Koch,Kathy Y Lee,Chunmei Liu,Z. Lewis Liu,Anne Bergstrom Lucas,Chitra Manohar,Garry Miyada,Zora Modrusan,Helen Parkes,Raj K. Puri,Laura H. Reid,Thomas B. Ryder,Marc L. Salit,Raymond R. Samaha,Uwe Scherf,Timothy J Sendera,Robert Setterquist,Leming Shi,Richard Shippy,Jesus Soriano,Elizabeth A. Wagar,Janet A. Warrington,Mickey Williams,Frederike Wilmer,Michael A Wilson,Paul K. Wolber,Xiaoning Wu,Renata Zadro +52 more
TL;DR: The External RNA Controls Consortium (ERCC) is developing commonly agreed-upon and tested controls for use in expression assays, a true industry-wide standard control.
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Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator.
TL;DR: It is demonstrated that cytosolic domains of human CFTR are sufficient to induce inhibition of rat epithelial Na+ currents (rENaC) when coexpressed in Xenopus oocytes and stimulated with 3‐isobutyl‐1‐methylxanthine (IBMX).
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Dysregulation of Gene Expression in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Mouse Substantia Nigra
Renee M. Miller,Linda M. Callahan,Cindy Casaceli,Linlin Chen,Gretchen L. Kiser,Buena Chui,Tamma Kaysser-Kranich,Timothy J Sendera,Chockalingam Palaniappan,Howard J. Federoff +9 more
TL;DR: Microarray analysis and integrative data mining were used to uncover pathways implicated in the progression of changes in dopaminergic neurons after MPTP administration and disclosed dysregulation of genes in three main areas related to neuronal function.
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Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease
Renee M. Miller,Gretchen L. Kiser,Tamma Kaysser-Kranich,Randall J. Lockner,Chockalingam Palaniappan,Howard J. Federoff +5 more
TL;DR: It is demonstrated that relatively few genes' expression levels can effectively distinguish between disease and control brains, and several interesting patterns of gene expression are identified that illuminate pathogenic cascades in Parkinson's disease.