Journal ArticleDOI
Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease
Renee M. Miller,Gretchen L. Kiser,Tamma Kaysser-Kranich,Randall J. Lockner,Chockalingam Palaniappan,Howard J. Federoff +5 more
TLDR
It is demonstrated that relatively few genes' expression levels can effectively distinguish between disease and control brains, and several interesting patterns of gene expression are identified that illuminate pathogenic cascades in Parkinson's disease.About:
This article is published in Neurobiology of Disease.The article was published on 2006-02-01. It has received 98 citations till now. The article focuses on the topics: Nigrostriatal pathway & Substantia nigra.read more
Citations
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Journal ArticleDOI
Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology
Filip Simunovic,Ming Yi,Yulei Wang,Laurel Macey,Lauren Brown,Anna M. Krichevsky,Susan L. Andersen,Robert M. Stephens,Francine M. Benes,Kai C. Sonntag +9 more
TL;DR: Laser microdissection is used to isolate single DA neurons from the substantia nigra pars compacta of controls and subjects with idiopathic Parkinson's disease matched for age and postmortem interval followed by microarrays to analyse gene expression profiling, which provide a 'molecular fingerprint identity' of late-stage Parkinson's Disease DA neurons that will advance understanding of the molecular pathology of this disease.
Journal ArticleDOI
Effects of gender on nigral gene expression and parkinson disease.
Ippolita Cantuti-Castelvetri,Christine E. Keller-McGandy,Bérengère Bouzou,Georgios Asteris,Timothy Clark,Matthew P. Frosch,David G. Standaert +6 more
TL;DR: The data reveal broad gender-based differences in gene expression in human dopaminergic neurons of SNc that may underlie the predisposition of males to PD and show that gender influences the response to PD, suggesting that the nature of the disease and the respond to treatment may be gender-dependent.
Journal ArticleDOI
Phenotypic Characterization of Retinoic Acid Differentiated SH-SY5Y Cells by Transcriptional Profiling
Joanna A. Korecka,Ronald E. van Kesteren,Eva Blaas,Sonia O. Spitzer,Jorke H. Kamstra,August B. Smit,Dick F. Swaab,Joost Verhaagen,Joost Verhaagen,Koen Bossers +9 more
TL;DR: It is demonstrated that RA induces a general neuronal differentiation program in SH-SY5Y cells and that these cells develop a predominantly mature DAergic-like neurotransmitter phenotype, characterized by increased dopamine levels together with a substantial suppression of other neurotransmitter phenotypes.
Journal ArticleDOI
Gene expression profiling in human neurodegenerative disease
Johnathan Cooper-Knock,Janine Kirby,Laura Ferraiuolo,Paul R. Heath,Magnus Rattray,Pamela J. Shaw +5 more
TL;DR: This Review summarizes microarray human GEP studies in the common neurodegenerative diseases amyotrophic lateral sclerosis (ALS), Parkinson disease (PD) and Alzheimer disease (AD) and provides a discussion of methodological considerations in microarray sample preparation and data analysis.
Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders.
TL;DR: This pathway- and network-driven model highlights several potential shared mechanisms in AD and PD that will inform future studies of these and other neurodegenerative disorders and suggests that biomarker and treatment strategies may require simultaneous targeting of multiple components, including some specific to disease stage, in order to assess and modulate neurodegenersation.
References
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Journal ArticleDOI
α-Synuclein Locus Triplication Causes Parkinson's Disease
Andrew B. Singleton,Matthew J. Farrer,Joshua C. Johnson,Amanda Singleton,Stephen Hague,Jennifer M. Kachergus,Mary M. Hulihan,Terhi Peuralinna,Amalia Dutra,Robert L. Nussbaum,Sarah Lincoln,Anthony Crawley,Melissa Hanson,Demetrius M. Maraganore,Charles H. Adler,Mark R. Cookson,Manfred D. Muenter,Melisa J. Baptista,David Miller,J. Blancato,John Hardy,Katrina Gwinn-Hardy +21 more
TL;DR: In this article, the α-synuclein was identified as the major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and of glial cell cytoplasmic inclusions.
Journal ArticleDOI
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
TL;DR: A clinical, morphological and neurochemical correlative study in patients with Parkinson's syndrome and Huntington's chorea is reported in this paper, where positive correlations can be established, within a certain range, between the severity of individual Parkinsonian symptoms (especially akinesia and tremor) and the degree, and also the site, of the disturbance of dopamine metabolism within the nuclei of the basal ganglia; and the sensitivity of the patients to levodopa's acute anti-akinesia effect.
Journal ArticleDOI
The ubiquitin pathway in Parkinson's disease
Elisabeth Leroy,Rebecca Boyer,Georg Auburger,Barbara Leube,Gudrun Ulm,Eva Mezey,G Harta,Michael J. Brownstein,Sobhanadditya Jonnalagada,Tanya Chernova,Anindya Dehejia,Christian Lavedan,Thomas Gasser,Peter J. Steinbach,Keith D. Wilkinson,Mihael H. Polymeropoulos +15 more
TL;DR: It is shown that in a German family with Parkinson's disease a missense mutation in the ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene causes a partial loss of the catalytic activity of this thiol protease, which could lead to aberrations in the proteolytic pathway and aggregation of proteins.
Journal ArticleDOI
Abnormalities of the electron transport chain in idiopathic parkinson's disease
TL;DR: It is hypothesized that the complex I abnormality may have an etiological role in the pathogenesis of Parkinson's disease and that this defect may be derived via the mitochondrial genome.
Journal ArticleDOI
Description of Parkinson's disease as a clinical syndrome.
TL;DR: Clinical fluctuations and dyskinesias are frequent complications of levodopa therapy; these, as well as some motor features of PD, improve by resetting the abnormal brain physiology towards normal by surgical therapy.
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