G
Guillermo Barreto
Researcher at Max Planck Society
Publications - 65
Citations - 3486
Guillermo Barreto is an academic researcher from Max Planck Society. The author has contributed to research in topics: Chromatin & Biology. The author has an hindex of 21, co-authored 52 publications receiving 2850 citations. Previous affiliations of Guillermo Barreto include Paris 12 Val de Marne University & University of Giessen.
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Journal ArticleDOI
Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones
Mona Saffarzadeh,Christiane Juenemann,Markus A. Queisser,Markus A. Queisser,Guenter Lochnit,Guillermo Barreto,Sebastian P. Galuska,Juergen Lohmeyer,Klaus T. Preissner +8 more
TL;DR: Data reveal the important role of protein components in NET, particularly histones, which may lead to host cell cytotoxicity and may be involved in lung tissue destruction.
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Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
Guillermo Barreto,Andrea Schäfer,Joachim Marhold,Dirk Stach,Suresh Kumar Swaminathan,Vikas Handa,Gabi Döderlein,Nicole Maltry,Wei Wu,Wei Wu,Frank Lyko,Christof Niehrs +11 more
TL;DR: It is shown that Gadd45a (growth arrest and DNA-damage-inducible protein 45 alpha), a nuclear protein involved in maintenance of genomic stability, DNA repair and suppression of cell growth, has a key role in active DNA demethylation.
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Nuclear reprogramming of human somatic cells by Xenopus egg extract requires BRG1
TL;DR: Nuclear reprogramming of permeabilized human cells using extracts from Xenopus laevis eggs and early embryos is demonstrated and upregulation of pluripotency markers Oct-4 and germ cell alkaline phosphatase (GCAP) in 293T cells and human primary leukocytes is shown.
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Transcriptional repression by the insulator protein CTCF involves histone deacetylases
Marcus Lutz,Les J. Burke,Guillermo Barreto,Frauke Goeman,Heiko Greb,Rüdiger Arnold,Holger Schultheiß,Alexander Brehm,Tony Kouzarides,Victor V. Lobanenkov,Rainer Renkawitz +10 more
TL;DR: It is suggested that CTCF driven repression is mediated in part by the recruitment of histone deacetylase activity by SIN3A, a candidate tumor suppressor protein that binds to highly divergent DNA sequences.
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Epigenetics in lung cancer diagnosis and therapy
Aditi Mehta,Stephanie Dobersch,Addi J. Romero-Olmedo,Addi J. Romero-Olmedo,Guillermo Barreto,Guillermo Barreto +5 more
TL;DR: This review summarizes the chromatin alterations in lung cancer, focusing on the diagnostic and therapeutic approaches targeting epigenetic modifications that could help to reduce the high case-fatality rate of this dreadful disease.