G
Gunilla B. Karlsson
Researcher at Harvard University
Publications - 11
Citations - 1491
Gunilla B. Karlsson is an academic researcher from Harvard University. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 11, co-authored 11 publications receiving 1471 citations. Previous affiliations of Gunilla B. Karlsson include Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys.
Keith A. Reimann,J T Li,Ronald S. Veazey,Matilda Halloran,In-Woo Park,Gunilla B. Karlsson,Joseph Sodroski,Norman L. Letvin +7 more
TL;DR: It is shown that after two serial in vivo passages by intravenous blood inoculation of naive rhesus monkeys, this SHIV (SHIV-89.6P) induced CD4 lymphopenia and an AIDS-like disease with wasting and opportunistic infections.
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Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection
Michael Farzan,Hyeryun Choe,Kathleen A. Martin,Luisa Marcon,Wolfgang Hofmann,Gunilla B. Karlsson,Ying Sun,Peter L Barrett,Nathalie E Marchand,Nancy Sullivan,Norma P. Gerard,Craig Gerard,Joseph Sodroski +12 more
TL;DR: Two orphan seven-transmembrane segment receptors, gpr1 and gpr15, serve as coreceptors for SIV, and are expressed in human alveolar macrophages, and may contribute to an understanding of viral variation and pathogenesis.
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Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys.
Gunilla B. Karlsson,Matilda Halloran,John Li,In-Woo Park,Raul Gomila,Keith A. Reimann,Michael K. Axthelm,Susan A. Iliff,Norman L. Letvin,Joseph Sodroski +9 more
TL;DR: The availability of pathogenic proviral clones should facilitate dissection of the molecular determinants of SHIV-89.6P virulence, and the molecular changes responsible for this increase in virulence were characterized.
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The Envelope Glycoprotein Ectodomains Determine the Efficiency of CD4+ T Lymphocyte Depletion in Simian– Human Immunodeficiency Virus–Infected Macaques
Gunilla B. Karlsson,Matilda Halloran,Dominik Schenten,Juliette Lee,Paul Racz,Klara Tenner-Racz,Judith Manola,Rebecca Gelman,Bijan Etemad-Moghadam,Elizabeth Desjardins,Richard T. Wyatt,Norma P. Gerard,Luisa Marcon,Luisa Marcon,David Margolin,John W. Fanton,Michael K. Axthelm,Norman L. Letvin,Joseph Sodroski +18 more
TL;DR: These studies identify the HIV-1 envelope glycoprotein ectodomains as determinants of CD4+ T lymphocyte loss in vivo and provide a foundation for studying pathogenic mechanisms.
Journal ArticleDOI
Changes in Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Responsible for the Pathogenicity of a Multiply Passaged Simian-Human Immunodeficiency Virus (SHIV-HXBc2)
Mark Cayabyab,Gunilla B. Karlsson,Bijan Etemad-Moghadam,Wolfgang Hofmann,Tavis D. Steenbeke,Matilda Halloran,John W. Fanton,Michael K. Axthelm,Norman L. Letvin,Joseph Sodroski +9 more
TL;DR: Changes in the envelope glycoproteins account for the ability of the passaged virus to deplete CD4+ T lymphocytes rapidly and specify increased replicative capacity and resistance to neutralization.