M
Mark Cayabyab
Researcher at Harvard University
Publications - 23
Citations - 1986
Mark Cayabyab is an academic researcher from Harvard University. The author has contributed to research in topics: Simian immunodeficiency virus & Glycoprotein. The author has an hindex of 16, co-authored 22 publications receiving 1918 citations. Previous affiliations of Mark Cayabyab include Beth Israel Deaconess Medical Center & Boston Children's Hospital.
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Journal ArticleDOI
Tyrosine Sulfation of the Amino Terminus of CCR5 Facilitates HIV-1 Entry
Michael Farzan,Tajib Mirzabekov,Peter Kolchinsky,Richard T. Wyatt,Mark Cayabyab,Norma P. Gerard,Norma P. Gerard,Craig Gerard,Craig Gerard,Joseph Sodroski,Hyeryun Choe,Hyeryun Choe +11 more
TL;DR: The chemokine receptor CCR5, a principal HIV-1 coreceptor, is posttranslationally modified by O-linked glycosylation and by sulfation of its N-terminal tyrosines, a modification common to primate immunodeficiency virus coreceptors.
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The Orphan Seven-Transmembrane Receptor Apj Supports the Entry of Primary T-Cell-Line-Tropic and Dualtropic Human Immunodeficiency Virus Type 1
Hyeryun Choe,Michael Farzan,Miriam K. Konkel,Kathleen A. Martin,Kathleen A. Martin,Ying Sun,Luisa Marcon,Mark Cayabyab,Mark Cayabyab,Michael Berman,Martin E. Dorf,Norma P. Gerard,Norma P. Gerard,Craig Gerard,Craig Gerard,Joseph Sodroski +15 more
TL;DR: In this article, Apj and CCR9 were identified as 7TMS proteins that can function as HIV-1 coreceptors, and mRNAs for both proteins were present in phytohemagglutinin- and interleukin-2-activated peripheral blood mononuclear cells.
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Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.
Paul R Gorry,Joann M. Taylor,Geoffrey H. Holm,Andrew Mehle,Tom Morgan,Mark Cayabyab,Michael Farzan,Hui Wang,Jeanne E. Bell,Kevin J. Kunstman,John P. Moore,Steven M. Wolinsky,Dana Gabuzda +12 more
TL;DR: The results predict the presence of HIV-1 variants with increased CCR5 affinity and reduced dependence on C CR5 and CD4 in the brains of some AIDS patients with central nervous system disease and suggest that R5 variants with increase CCR 5 affinity may represent a pathogenic viral phenotype contributing to the neurodegenerative manifestations of AIDS.
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Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication
Peter Kolchinsky,Tajib Mirzabekov,Michael Farzan,Enko Kiprilov,Mark Cayabyab,Larissa J. Mooney,Hyeryun Choe,Joseph Sodroski +7 more
TL;DR: A major function of CD4 binding in the entry of primary HIV-1 isolates can be bypassed by changes in the gp120 V1-V2 elements, which allow the envelope glycoproteins to assume a conformation competent for CCR5 binding.
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Exploring the Stereochemistry of CXCR4-Peptide Recognition and Inhibiting HIV-1 Entry with d-Peptides Derived from Chemokines
Naiming Zhou,Zhaowen Luo,Jiansong Luo,Xuejun Fan,Mark Cayabyab,Megumi Hiraoka,Dongxiang Liu,Dongxiang Liu,Xiaobing Han,James J. Pesavento,Chang-Zhi Dong,Youli Wang,Jing An,Hideko Kaji,Joseph Sodroski,Ziwei Huang,Ziwei Huang +16 more
TL;DR: Acting as CXCR4 antagonists and with much higher biological stability than l-counterparts, the d-peptides showed significant activity in inhibiting the replication of CX CR4-dependent HIV-1 strains.