G
Gunnar R. Mair
Researcher at Heidelberg University
Publications - 63
Citations - 4194
Gunnar R. Mair is an academic researcher from Heidelberg University. The author has contributed to research in topics: Plasmodium berghei & Plasmodium. The author has an hindex of 32, co-authored 60 publications receiving 3769 citations. Previous affiliations of Gunnar R. Mair include University of Innsbruck & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
High efficiency transfection of Plasmodium berghei facilitates novel selection procedures.
Chris J. Janse,Blandine Franke-Fayard,Gunnar R. Mair,Jai Ramesar,Corinna Thiel,Sabine Engelmann,Kai Matuschewski,Geert-Jan van Gemert,Robert W. Sauerwein,Andrew P. Waters +9 more
TL;DR: The combination of enhanced transfection efficiency and a versatile rodent model provides a basis for the further development of novel tools for high throughput genome manipulation.
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Regulation of sexual development of Plasmodium by translational repression.
Gunnar R. Mair,Joanna A. M. Braks,Lindsey S. Garver,Joop Wiegant,Neil Hall,Roeland W. Dirks,Shahid M. Khan,George Dimopoulos,Chris J. Janse,Andrew P. Waters +9 more
TL;DR: Translational repression and mRNA turnover were shown to influence stage-specific gene expression in the protozoan Plasmodium and the DDX6-class RNA helicase, DOZI, is found in a complex with mRNA species in cytoplasmic bodies of female, blood-stage gametocytes.
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Proteome Analysis of Separated Male and Female Gametocytes Reveals Novel Sex-Specific Plasmodium Biology
Shahid M. Khan,Blandine Franke-Fayard,Gunnar R. Mair,Edwin Lasonder,Edwin Lasonder,Chris J. Janse,Matthias Mann,Andrew P. Waters +7 more
TL;DR: The male gametocyte has the most distinct proteome, containing many proteins involved in flagellar-based motility and rapid genome replication, and new sex-specific regulatory pathways were defined.
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Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development.
Gunnar R. Mair,Edwin Lasonder,Lindsey S. Garver,Lindsey S. Garver,Blandine Franke-Fayard,Celine Carret,Joop Wiegant,Roeland W. Dirks,George Dimopoulos,Chris J. Janse,Andrew P. Waters,Andrew P. Waters +11 more
TL;DR: Plasmodium P granules is defined as an ancient mRNP whose protein core has remained evolutionarily conserved from single-cell organisms to germ cells of multi-cellular animals and stores translationally silent mRNAs that are critical for early post-fertilization development during the initial stages of mosquito infection.
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Proteomic Profiling of Plasmodium Sporozoite Maturation Identifies New Proteins Essential for Parasite Development and Infectivity
Edwin Lasonder,Edwin Lasonder,Chris J. Janse,Geert-Jan van Gemert,Gunnar R. Mair,Adriaan M. W. Vermunt,Bruno Douradinha,Vera van Noort,Martijn A. Huynen,Adrian J. F. Luty,Hans Kroeze,Shahid M. Khan,Robert W. Sauerwein,Andrew P. Waters,Matthias Mann,Hendrik G. Stunnenberg +15 more
TL;DR: Light is shed on the development and maturation of the malaria parasite in an Anopheles mosquito and also proteins that may be essential for sporozoite infectivity to humans are identified.