H
Hans Kroeze
Researcher at Leiden University Medical Center
Publications - 24
Citations - 1114
Hans Kroeze is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Plasmodium berghei & Plasmodium falciparum. The author has an hindex of 13, co-authored 21 publications receiving 964 citations. Previous affiliations of Hans Kroeze include Leiden University.
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Journal ArticleDOI
Proteomic Profiling of Plasmodium Sporozoite Maturation Identifies New Proteins Essential for Parasite Development and Infectivity
Edwin Lasonder,Edwin Lasonder,Chris J. Janse,Geert-Jan van Gemert,Gunnar R. Mair,Adriaan M. W. Vermunt,Bruno Douradinha,Vera van Noort,Martijn A. Huynen,Adrian J. F. Luty,Hans Kroeze,Shahid M. Khan,Robert W. Sauerwein,Andrew P. Waters,Matthias Mann,Hendrik G. Stunnenberg +15 more
TL;DR: Light is shed on the development and maturation of the malaria parasite in an Anopheles mosquito and also proteins that may be essential for sporozoite infectivity to humans are identified.
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Three Members of the 6-cys Protein Family of /Plasmodium/ Play a Role in Gamete Fertility
Melissa R. van Dijk,Ben C. L. van Schaijk,Shahid M. Khan,Maaike W. van Dooren,Jai Ramesar,Szymon Kaczanowski,Geert-Jan van Gemert,Hans Kroeze,Hendrik G. Stunnenberg,Wijnand Eling,Robert W. Sauerwein,Andrew P. Waters,Chris J. Janse +12 more
TL;DR: Results indicate that the P. berghei 6-cys family contains a number of proteins that are either male or female specific ligands that play an important role in gamete recognition and/or attachment.
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Egress of Plasmodium berghei gametes from their host erythrocyte is mediated by the MDV‐1/PEG3 protein
Marta Ponzi,Inga Siden-Kiamos,Lucia Bertuccini,Chiara Currà,Hans Kroeze,Grazia Camarda,Tomasino Pace,Blandine Franke-Fayard,Eliane C. Laurentino,Christos Louis,Christos Louis,Andrew P. Waters,Chris J. Janse,Pietro Alano +13 more
TL;DR: The characterization of a Plasmodium berghei protein that is involved in egress of both male and female gametes from the host erythrocyte is reported, demonstrating that emergence from theHost cell of male andFemalegametes relies on a common, MDV‐1/PEG3‐dependent mechanism that is distinct from mechanisms used by asexual parasites.
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The Plasmodium TRAP/MIC2 family member, TRAP‐Like Protein (TLP), is involved in tissue traversal by sporozoites
Cristina K. Moreira,Thomas J. Templeton,Catherine Lavazec,Rhian E. Hayward,Charlotte V. Hobbs,Hans Kroeze,Chris J. Janse,Andrew P. Waters,Photini Sinnis,Alida Coppi +9 more
TL;DR: A new member of the TRAP/MIC2 family, named TRAP‐Like Protein (TLP), that is highly conserved within the Plasmodium genus is characterized, indicating a role of TLP in cell traversal by sporozoites.
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Development and application of a positive-negative selectable marker system for use in reverse genetics in Plasmodium.
TL;DR: A negative selection system based upon transgenic expression of a bifunctional protein (yFCU) combining yeast cytosine deaminase and uridyl phosphoribosyl transferase (UPRT) activity in P.berghei followed by in vivo selection with the prodrug 5-fluorocytosine is reported.