Guochun Gong

TL;DR: It is demonstrated that lncRNAs play critical roles in vivo and provides a framework and impetus for future larger-scale functional investigation into the roles of lncRNA molecules.

TL;DR: The data suggest that C9orf72 regulates immune homeostasis and an autoimmune response reminiscent of systemic lupus erythematosus (SLE) occurs in its absence, implying that haploinsufficiency is unlikely to be the causative factor in C9ALS/FTD pathology.

TL;DR: This study shows that lincRNAs are a new class of encoded molecules that, like proteins, serve essential and important functional roles in embryonic development, physiology, and homeostasis of a broad array of tissues and organs in mammals.

TL;DR: In this article, a set of constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinases in an differentiated cell but not an undifferentiated cell.

TL;DR: In this article, the authors describe embryonic stem (ES) cell growth conditions that promote the production of healthy, anatomically normal fertile and fecund female F0 generation mice completely derived from gene-targeted XY male ES cells.