Guoqiang Xing

TL;DR: In stressed rats, the 5-HT2A receptor-mediated facilitative actions were severely impaired, which might result in an amygdala circuitry with hyperexcitability, and a lower threshold of activation, and thus be an important mechanism underlying the emergence of stress-associated psychiatric symptoms.

TL;DR: Genetic variation and BDNF levels in plasma of the subjects with PTSD were significantly higher than those in the non-PTSD controls, agreeing with evidence suggesting that BDNF is involved in the development of PTSD.

TL;DR: Kainate receptor-mediated synaptic facilitation generalizes to include inactive afferent synapses on the target neurons, and therefore contrasts with other types of activity-dependent enduring synapticfacilitation that are input-pathway specific.

TL;DR: Analysis of the small subset of genes studied in all highland populations showed normoxia induced gene expression changes in Andeans, but not in Ethiopians nor Himalayan controls, consistent with physiologic studies in which Ethiopians and Himalayans show a lack of responsiveness to hypoxia of the cerebral circulation and of the hypoxic ventilatory drive.

TL;DR: The results suggest that the CB1 in the PFC may play a significant role in regulating mood and anxiety symptoms, and the advantage of utilizing data from postmortem brain tissue and a mouse model of fear to enhance the understanding of the role of the cannabinoid receptors in Mood and anxiety disorders.