G
Guy-Franck Richard
Researcher at Pasteur Institute
Publications - 61
Citations - 4699
Guy-Franck Richard is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 27, co-authored 56 publications receiving 4416 citations. Previous affiliations of Guy-Franck Richard include Brandeis University & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Mini- and microsatellite expansions: the recombination connection.
TL;DR: Data connecting tandem repeat rearrangements and recombinations in humans and in eukaryotic model organisms is reviewed, and the possible role of recombination in trinucleotide repeat expansions in human neurological disorders is discussed.
Journal ArticleDOI
Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11-RAD50-XRS2 complex.
Guy-Franck Richard,Guy-Franck Richard,Geoffrey M. Goellner,Cynthia T. McMurray,James E. Haber +4 more
TL;DR: The Mre11 complex appears to be directly involved in removing CAG or CTG hairpins that arise frequently during DNA synthesis accompanying gene conversion of these trinucleotide repeats.
Journal ArticleDOI
Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast
Sophie Loeillet,Benoit Palancade,Marina Cartron,Agnès Thierry,Guy-Franck Richard,Bernard Dujon,Valérie Doye,Alain Nicolas +7 more
TL;DR: The results of the SGA analysis of the collection of non-essential yeast genes against the rad27Delta mutation resulted in the identification of a novel synthetic lethal interaction conferred by mutations affecting the Nup84 nuclear pore subcomplex (nup133Delta, nup120Delta and nup84Delta).
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Pichia sorbitophila, an Interspecies Yeast Hybrid, Reveals Early Steps of Genome Resolution After Polyploidization
Véronique Leh Louis,Laurence Despons,Anne Friedrich,Tiphaine Martin,Pascal Durrens,Serge Casaregola,Cécile Neuvéglise,Cécile Fairhead,Christian Marck,José Almeida Cruz,Marie Laure Straub,Valérie Kugler,Christine Sacerdot,Zlatyo Uzunov,Agnès Thierry,Stéphanie Weiss,Claudine Bleykasten,Jacky de Montigny,Noémie Jacques,Paul P. Jung,Marc Lemaire,Sandrine Mallet,Guillaume Morel,Guy-Franck Richard,Anasua Sarkar,Guilhem Savel,Joseph Schacherer,Marie Line Seret,Emmanuel Talla,Gaelle Samson,Claire Jubin,Julie Poulain,Benoit Vacherie,Valérie Barbe,Eric Pelletier,David James Sherman,Eric Westhof,Jean Weissenbach,Philippe Baret,Patrick Wincker,Claude Gaillardin,Bernard Dujon,Jean Luc Souciet +42 more
TL;DR: This article shows that an osmotolerant yeast species, Pichia sorbitophila, recently isolated in a concentrated sorbitol solution in industry, illustrates this last situation and finds that the physiological characteristics of this new yeast species are determined by specific but unequal contributions of its two parents.
Journal ArticleDOI
Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats.
TL;DR: It is shown that deletion of RAD27, a gene involved in the processing of Okazaki fragments, increases the frequency of contractions tenfold and suggests that both gene conversion and single-strand annealing are major sources of trinucleotide repeat rearrangements.