H
H.-S. Vincent Chen
Researcher at Brigham and Women's Hospital
Publications - 6
Citations - 1315
H.-S. Vincent Chen is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: NMDA receptor & Glutamate receptor. The author has an hindex of 5, co-authored 6 publications receiving 1189 citations. Previous affiliations of H.-S. Vincent Chen include Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A.
Saumya Das,Yasnory F. Sasaki,Thomas Rothe,Louis S. Premkumar,Mari A. Takasu,James E. Crandall,Pieter Dikkes,David A. Conner,P.V. Rayudu,Wing S Cheung,H.-S. Vincent Chen,Stuart A. Lipton,Stuart A. Lipton,Nobuki Nakanishi +13 more
TL;DR: The characterization of a regulatory NMDAR subunit, NR3A, is reported, which is expressed primarily during brain development and suggested to be involved in the development of synaptic elements by modulating N MDAR activity.
Journal ArticleDOI
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
Maria Talantova,Sara Sanz-Blasco,Xiaofei Zhang,Peng Xia,Mohd Waseem Akhtar,Shu-ichi Okamoto,Gustavo Dziewczapolski,Tomohiro Nakamura,Gang Cao,Alexander E. Pratt,Alexander E. Pratt,Yeon-Joo Kang,Shichun Tu,Elena Molokanova,Scott R. McKercher,Samuel Andrew Hires,Hagit Sason,David G. Stouffer,Matthew W. Buczynski,James P. Solomon,Sarah Michael,Evan T. Powers,Jeffery W. Kelly,Amanda J. Roberts,Gary Tong,Traci Fang-Newmeyer,James C. Parker,Emily A. Holland,Dongxian Zhang,Nobuki Nakanishi,H.-S. Vincent Chen,Herman Wolosker,Yuqiang Wang,Loren H. Parsons,Rajesh Ambasudhan,Eliezer Masliah,Stephen F. Heinemann,Juan C. Piña-Crespo,Stuart A. Lipton +38 more
TL;DR: The improved eNMDAR antagonist NitroMemantine, which selectively inhibits extrasynaptic over physiological synaptic NMDAR activity, protects synapses from Aβ-induced damage both in vitro and in vivo.
Journal ArticleDOI
Neuroprotection by the NR3A Subunit of the NMDA Receptor
Nobuki Nakanishi,Shichun Tu,Yeonsook Shin,Jiankun Cui,Toru Kurokawa,Dongxian Zhang,H.-S. Vincent Chen,Gary Tong,Stuart A. Lipton +8 more
TL;DR: It is found that cultured neurons prepared from NR3A knock-out mice displayed greater sensitivity to damage by NMDA application than wild-type (WT) neurons, and exogenously addedNR3A increases neuroprotection and could be potentially exploited as a therapeutic.
Journal ArticleDOI
Neuroprotective versus neurodestructive effects of NO-related species
TL;DR: Transfer of the NO group to cysteine sulfhydryls on the NMDA receptor or other proteins, known as S‐nitrosylation, is becoming recognized as a ubiquitous regulatory reaction, akin to phosphorylation, and represents a form of redox modulation in diverse tissues including the brain.
Journal ArticleDOI
The pharmacology of aminoadamantane nitrates.
Yuqiang Wang,Jerry Eu,Mark Washburn,Tong Gong,H.-S. Vincent Chen,W. Larrick James,Stuart A. Lipton,Jonathan S. Stamler,Gregory T. Went,Seth Porter +9 more
TL;DR: These tests provide an initial indication of which of the compounds may have enhanced activity relative to memantine and provide guidance for the synthesis of additional compounds that are likely to have the properties that are being sought.