Hadil El-Sammak

TL;DR: It is shown that revascularization requires a coordinated multi-tissue response culminating with the formation of a complex vascular network available as a scaffold for cardiomyocyte repopulation.

TL;DR: The findings reveal new roles for cardiac metabolism and the PDK‐PDC axis in cardiomyocyte behavior following cardiac injury and find that PDK activity can modulate cell cycle progression and protrusive activity in mammalianCardiomyocytes in culture.

TL;DR: Zebrafish loss of pitx2c in zebrafish leads to adult cardiac phenotypes with substantial similarities to pathologies observed in AF patients, including arrhythmia, atrial conduction defects, sarcomere disassembly, and altered cardiac metabolism, which increases understanding of how developmental perturbations can predispose to functional defects in the adult heart.

TL;DR: In this article , the authors dissected the diversity of activated cell states in the regenerating zebrafish heart based on single-cell transcriptomics and spatiotemporal analysis, and found that activated fibroblasts were derived from two separate sources: the epicardium and the endocardium.

TL;DR: Data show that after cardiac injury, coronary endothelial cells upregulate vegfc to promote coronary network reestablishment and cardiac regeneration, and that Vegfc signaling is required for their proliferation during regeneration.