Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.
Rubén Marín-Juez,Hadil El-Sammak,Christian S. M. Helker,Aosa Kamezaki,Sri Teja Mullapuli,Sofia-Iris Bibli,Matthew J. Foglia,Ingrid Fleming,Kenneth D. Poss,Didier Y.R. Stainier +9 more
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TLDR
It is shown that revascularization requires a coordinated multi-tissue response culminating with the formation of a complex vascular network available as a scaffold for cardiomyocyte repopulation.About:
This article is published in Developmental Cell.The article was published on 2019-11-18 and is currently open access. It has received 73 citations till now. The article focuses on the topics: Revascularization & Endocardium.read more
Citations
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The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration
Marco Bianchi,Rosanna Mezzapelle +1 more
TL;DR: A deeper understanding of the complex signaling originating from CXCR4 is needed to exploit the opportunities to repair damaged organs safely and effectively.
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AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration.
Arica Beisaw,Carsten Kuenne,Stefan Guenther,Julia Dallmann,Chi-Chung Wu,Mette Bentsen,Mario Looso,Didier Y.R. Stainier +7 more
TL;DR: AP-1 transcription factors play an essential role in the cardiomyocyte response to injury by regulating chromatin accessibility changes, thereby allowing the activation of gene expression programs that promote cardiomeocyte dedifferentiation, proliferation, and protrusion into the injured area.
Journal ArticleDOI
Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish.
Ryuichi Fukuda,Rubén Marín-Juez,Hadil El-Sammak,Arica Beisaw,Radhan Ramadass,Carsten Kuenne,Stefan Guenther,Anne Konzer,Aditya M. Bhagwat,Johannes Graumann,Didier Y.R. Stainier +10 more
TL;DR: The findings reveal new roles for cardiac metabolism and the PDK‐PDC axis in cardiomyocyte behavior following cardiac injury and find that PDK activity can modulate cell cycle progression and protrusive activity in mammalianCardiomyocytes in culture.
Journal ArticleDOI
Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms.
Long Zhao,Feng Gao,Shan Gao,Yujun Liang,Hongan Long,Zhiyi Lv,Ying Su,Naihao Ye,Liusuo Zhang,Chengtian Zhao,Xiaoyu Wang,Weibo Song,Shicui Zhang,Bo Dong +13 more
TL;DR: A review of the recent work on the regulatory signaling of developmental and regeneration processes, environmental adaptation, and evolutionary mechanisms using both the existing model animals such as zebrafish and Drosophila, and the emerging nonstandard model organisms including amphioxus, ascidian, ciliates, single-celled phytoplankton, and marine nematode is presented in this paper.
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HIF in the heart: development, metabolism, ischemia, and atherosclerosis
TL;DR: In this article, the authors review the actions of HIF1, HIF2, and HIF3 in the heart, from their roles in development and metabolism to their activity in regeneration and preconditioning strategies.
References
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Coronary-Artery Revascularization before Elective Major Vascular Surgery
Edward O. McFalls,Herbert B. Ward,Thomas E. Moritz,Steven Goldman,William C. Krupski,Fred N. Littooy,Gordon L. Pierpont,Steve Santilli,Joseph H. Rapp,Joseph H. Rapp,Brack Hattler,Kendrick A. Shunk,Kendrick A. Shunk,Connie Jaenicke,Lizy Thottapurathu,Nancy Ellis,Domenic J. Reda,William G. Henderson +17 more
TL;DR: In this paper, the authors randomly assigned patients at increased risk for perioperative cardiac complications and clinically significant coronary artery disease to undergo either revascularization or no revascularisation before elective major vascular surgery.
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Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
Kazu Kikuchi,Jennifer E. Holdway,Andreas A. Werdich,Ryan M. Anderson,Yi Fang,Gregory F. Egnaczyk,Gregory F. Egnaczyk,Todd Evans,Calum A. MacRae,Didier Y.R. Stainier,Kenneth D. Poss +10 more
TL;DR: The results indicate that electrically coupled cardiac muscle regenerates after resection injury, primarily through activation and expansion of cardiomyocyte populations, which have implications for promoting regeneration of the injured human heart.