M
Mark R. Lundquist
Researcher at Cornell University
Publications - 10
Citations - 1807
Mark R. Lundquist is an academic researcher from Cornell University. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Kinase. The author has an hindex of 6, co-authored 9 publications receiving 1174 citations.
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Journal ArticleDOI
Chromosomal instability drives metastasis through a cytosolic DNA response.
Samuel F. Bakhoum,Samuel F. Bakhoum,Bryan Ngo,Ashley M. Laughney,Julie Ann Cavallo,Julie Ann Cavallo,Charles J. Murphy,Peter Ly,Pragya Shah,Roshan K. Sriram,Thomas B.K. Watkins,Neil K. Taunk,Mercedes Duran,Mercedes Duran,Chantal Pauli,Christine Shaw,Kalyani Chadalavada,Vinagolu K. Rajasekhar,Giulio Genovese,Subramanian Venkatesan,Nicolai Juul Birkbak,Nicholas McGranahan,Mark R. Lundquist,Quincey LaPlant,John H. Healey,Olivier Elemento,Christine H. Chung,Nancy Y. Lee,Marcin Imielenski,Gouri Nanjangud,Dana Pe'er,Don W. Cleveland,Simon N. Powell,Jan Lammerding,Charles Swanton,Lewis C. Cantley +35 more
TL;DR: It is shown that chromosomally unstable tumour cells co-opt chronic activation of innate immune pathways to spread to distant organs by sustaining a tumour cell-autonomous response to cytosolic DNA.
Journal ArticleDOI
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Benjamin D. Hopkins,Chantal Pauli,Chantal Pauli,Xing Du,Diana G. Wang,Diana G. Wang,Xiang Li,David Wu,Solomon C. Amadiume,Marcus D. Goncalves,Cindy Hodakoski,Mark R. Lundquist,Rohan Bareja,Rohan Bareja,Yan Ma,Emily M. Harris,Andrea Sboner,Himisha Beltran,Himisha Beltran,Mark A. Rubin,Mark A. Rubin,Siddhartha Mukherjee,Lewis C. Cantley +22 more
TL;DR: It is shown, in several model tumours in mice, that systemic glucose–insulin feedback caused by targeted inhibition of this pathway is sufficient to activate PI3K signalling, even in the presence ofPI3K inhibitors.
Journal ArticleDOI
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton
Hai Hu,Ashish Juvekar,Costas A. Lyssiotis,Evan C. Lien,John G. Albeck,Doogie Oh,Gopal Varma,Yin P Hung,Soumya Ullas,Josh Lauring,Pankaj Seth,Mark R. Lundquist,Dean R. Tolan,Aaron K. Grant,Daniel J. Needleman,John M. Asara,Lewis C. Cantley,Gerburg M. Wulf +17 more
TL;DR: A master regulatory function of PI3K is pointed toward that integrates an epithelial cell's metabolism and its form, shape, and function, coordinating glycolysis with the energy-intensive dynamics of actin remodeling.
PatentDOI
Modification of nuclear actin by mical-2 regulates srf signaling
TL;DR: Redox modification of nuclear actin is identified as a regulatory switch that mediates SRF/MRTF-A-dependent gene transcription that exhibits efficacy in various preclinical disease models.
Journal ArticleDOI
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.
Mark R. Lundquist,Marcus D. Goncalves,Ryan M. Loughran,Elite Possik,Tarika Vijayaraghavan,Annan Yang,Chantal Pauli,Chantal Pauli,Archna Ravi,Akanksha Verma,Zhiwei Yang,Jared L. Johnson,Jenny C.Y. Wong,Yilun Ma,Katie Seo-Kyoung Hwang,David Weinkove,Nullin Divecha,John M. Asara,Olivier Elemento,Mark A. Rubin,Mark A. Rubin,Alec C. Kimmelman,Arnim Pause,Lewis C. Cantley,Brooke M. Emerling +24 more
TL;DR: The results suggest that this alternative pathway for PI-4, 5-P2 synthesis evolved, in part, to enhance the ability of multicellular organisms to survive starvation.