H
Hai Yu
Researcher at University of California, Davis
Publications - 252
Citations - 9928
Hai Yu is an academic researcher from University of California, Davis. The author has contributed to research in topics: Sialic acid & Glycan. The author has an hindex of 52, co-authored 252 publications receiving 8571 citations. Previous affiliations of Hai Yu include Northwest A&F University & University of Leeds.
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Journal ArticleDOI
Efficient Chemoenzymatic Synthesis of an N-glycan Isomer Library.
Lei Li,Yunpeng Liu,Cheng Ma,Jingyao Qu,Angie D. Calderon,Baolin Wu,Na Wei,Xuan Wang,Yuxi Guo,Zhongying Xiao,Jing Song,Go Sugiarto,Yanhong Li,Hai Yu,Xi Chen,Peng George Wang +15 more
TL;DR: An efficient chemoenzymatic synthesis strategy and a HILIC-based purification approach enabled rapid access to an N-glycan isomer library.
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Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP)
Musleh M. Muthana,Jingyao Qu,Yanhong Li,Lei Zhang,Hai Yu,Li Ding,Li Ding,Hamed Malekan,Xi Chen +8 more
TL;DR: A promiscuous UDP-sugar pyrophosphorylase was cloned from Bifidobacterium longum strain ATCC55813 and used efficiently with a Pasteurella multocida inorganic Pyrophosphatase with or without a monosaccharide 1-kinase for one-pot multienzyme synthesis of UDP-galactose, UDP-glucose, and their derivatives.
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Host adaptation of a bacterial toxin from the human pathogen salmonella typhi.
Lingquan Deng,Jeongmin Song,Xiang Gao,Jiawei Wang,Hai Yu,Xi Chen,Nissi Varki,Yuko Naito-Matsui,Jorge E. Galán,Ajit Varki +9 more
TL;DR: The atomic structure of typhoid toxin bound to Neu5Ac reveals the structural bases for its binding specificity and provides insight into the molecular bases for Salmonella Typhi's host specificity and may help the development of therapies for typhoid fever.
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Crystal Structures of Pasteurella multocida Sialyltransferase Complexes with Acceptor and Donor Analogues Reveal Substrate Binding Sites and Catalytic Mechanism.
Lisheng Ni,Harshal A. Chokhawala,Hongzhi Cao,Ryan Henning,Laura Ng,Shengshu Huang,Hai Yu,Xi Chen,Andrew J. Fisher +8 more
TL;DR: Structural and kinetic data support a direct displacement mechanism involving an oxocarbenium ion-like transition state assisted with Asp141 serving as a general base to activate the acceptor hydroxyl group.
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One-pot multienzyme (OPME) systems for chemoenzymatic synthesis of carbohydrates
TL;DR: This Perspective summarizes the work of the authors and collaborators on the development of glycosyltransferase-based OPME systems for carbohydrate synthesis and defines the structures of the products.