Hannah J. Gaunt

TL;DR: The data suggest that Piezo1 channels sense physical activity to advantageously reset vascular control and are a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, leading to vasoconstriction.

TL;DR: The unexpected possibility for the rapid and selective killing of renal cancer cells through activation of calcium-permeable nonselective transient receptor potential canonical (TRPC) calcium channels by the sesquiterpene (-)-englerin A is shown.

TL;DR: The mechanosensitive Piezo1 channel has important roles in vascular physiology and disease and Yoda1 is a small‐molecule agonist, but the pharmacology of these channels is otherwise limited.

TL;DR: Identification of an important experimental tool compound is suggested, which has much higher potency for inhibiting TRPC1/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC2-permeable non-selective cationic channel family.

TL;DR: The data suggest that Piezo1 is an important molecular determinant of blood flow sensitivity in the placenta and establishing and manipulating the molecular mechanisms regulating shear stress sensing could lead to novel therapeutic strategies to improve blood flow in theplacenta.