L
Lynn McKeown
Researcher at University of Leeds
Publications - 26
Citations - 1457
Lynn McKeown is an academic researcher from University of Leeds. The author has contributed to research in topics: Voltage-dependent calcium channel & Transient receptor potential channel. The author has an hindex of 13, co-authored 24 publications receiving 1186 citations. Previous affiliations of Lynn McKeown include University of Manchester & St James's University Hospital.
Papers
More filters
Journal ArticleDOI
Piezo1 integration of vascular architecture with physiological force
Jing Li,Bing Hou,Sarka Tumova,Katsuhiko Muraki,Alexander F. Bruns,Melanie J. Ludlow,Alicia Sedo,Adam J. Hyman,Lynn McKeown,Richard S. Young,Richard S. Young,Nadira Yuldasheva,Yasser Majeed,Lesley A. Wilson,Baptiste Rode,Marc A. Bailey,Hyejeong R. Kim,Zhaojun Fu,Deborah Angela Louise Carter,Jan Bilton,Helen Imrie,Paul Ajuh,T. Neil Dear,Richard M Cubbon,Mark T. Kearney,K. Raj Prasad,Paul C. Evans,Justin F. X. Ainscough,David J. Beech +28 more
TL;DR: Piezo1 channels are shown as sensors of frictional force (shear stress) and determinants of vascular structure in both development and adult physiology and the data suggest that Piezo 1 channels function as pivotal integrators in vascular biology.
Journal ArticleDOI
Orai1 and CRAC Channel Dependence of VEGF-Activated Ca2+ Entry and Endothelial Tube Formation
Jing Li,Richard M Cubbon,Lesley A. Wilson,Mohamed S Amer,Mohamed S Amer,Lynn McKeown,Bing Hou,Yasser Majeed,Sarka Tumova,Victoria A.L. Seymour,Hilary Taylor,Martin Stacey,David J. O'Regan,Richard Foster,Karen E. Porter,Mark T. Kearney,David J. Beech +16 more
TL;DR: Positive roles for Orai1 and CRAC channels in VEGF-evoked calcium entry and new opportunity for chemical modulation of angiogenesis are suggested.
Journal ArticleDOI
Pregnenolone Sulphate- and Cholesterol-Regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction
Jacqueline Naylor,Jing Li,Carol J. Milligan,Fanning Zeng,Piruthivi Sukumar,Bing Hou,Alicia Sedo,Nadira Yuldasheva,Yasser Majeed,Dhananjay Beri,Shan Jiang,Victoria A.L. Seymour,Lynn McKeown,Bhaskar Kumar,Christian Harteneck,David J. O'Regan,Stephen B. Wheatcroft,Mark T. Kearney,Clare A. Jones,Karen E. Porter,David J. Beech +20 more
TL;DR: The data suggest functional relevance of TRPM3 in contractile and proliferating phenotypes of vascular smooth muscle cells, significance of constitutive channel activity, regulation by cholesterol, and potential value of pregnenolone sulfate in therapeutic vascular modulation.
Journal ArticleDOI
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels
Hussein N. Rubaiy,Melanie J. Ludlow,Matthias Henrot,Hannah J. Gaunt,Katarina T. Miteva,Sin Ying Cheung,Yasuyuki Tanahashi,Nurasyikin Hamzah,Katie E. Musialowski,Nicola M Blythe,Hollie L. Appleby,Marc A. Bailey,Lynn McKeown,Roger Taylor,Richard Foster,Herbert Waldmann,Peter Nussbaumer,Mathias Christmann,Robin S. Bon,Katsuhiko Muraki,David J. Beech +20 more
TL;DR: Identification of an important experimental tool compound is suggested, which has much higher potency for inhibiting TRPC1/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC2-permeable non-selective cationic channel family.
Journal ArticleDOI
Nanomolar potency and selectivity of a Ca2+ release‐activated Ca2+ channel inhibitor against store‐operated Ca2+ entry and migration of vascular smooth muscle cells
Jing Li,Lynn McKeown,Ogooluwa Ojelabi,Martin Stacey,Richard Foster,David J. O'Regan,Karen E. Porter,David J. Beech +7 more
TL;DR: The aim was to advance the understanding of Orai proteins and identify a specific inhibitor of the associated calcium entry mechanism in vascular smooth muscle cells (VSMCs).