Alida Coppi

TL;DR: Synthetic chemistry and transfection studies concluding that Plasmodium FabI is not the target of the antimalarial activity of triclosan, an inhibitor of bacterial FabI, illuminate key differences between liver- and blood-stage parasites in their requirements for host versus de novo synthesized fatty acids, and create new prospects for stage-specific antimalaria interventions.

TL;DR: Conformational changes influence functional properties of circumsporozoite protein expressed on the surface of Plasmodium sporozoites.

TL;DR: It is found that drainage of approximately 20% of the sporozoite inoculum to the lymphatics is associated with a significant enlargement of the draining lymph node, a response not observed after intravenous inoculation.

TL;DR: It is shown that sporozoites of the rodent malaria parasite Plasmodium berghei use the sulfation level of host heparan sulfate proteoglycans (HSPGs) to navigate within the mammalian host.

TL;DR: It is shown that CSP is proteolytically cleaved by a papain family cysteine protease of parasite origin, and data suggest that the highly conserved region I, found just before the repeat region, contains the cleavage site.