H
Hans M.G. Princen
Researcher at Netherlands Organisation for Applied Scientific Research
Publications - 232
Citations - 10776
Hans M.G. Princen is an academic researcher from Netherlands Organisation for Applied Scientific Research. The author has contributed to research in topics: Cholesterol & Apolipoprotein E. The author has an hindex of 54, co-authored 227 publications receiving 9952 citations. Previous affiliations of Hans M.G. Princen include Pasteur Institute & Leiden University.
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Journal ArticleDOI
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Frederick E. Dewey,Viktoria Gusarova,Richard L Dunbar,Colm O'Dushlaine,Claudia Schurmann,Omri Gottesman,Shane McCarthy,Cristopher V. Van Hout,Shannon Bruse,Hayes Dansky,Joseph B. Leader,Michael F. Murray,Marylyn D. Ritchie,H. Lester Kirchner,Lukas Habegger,Alex Lopez,John Penn,An Zhao,Weiping Shao,Neil Stahl,Andrew J. Murphy,Sara Hamon,Aurelie Bouzelmat,Rick Zhang,Brad Shumel,Robert Pordy,Daniel A. Gipe,Gary Herman,Wayne H-H Sheu,I-Te Lee,I-Te Lee,Kae-Woei Liang,Kae-Woei Liang,Xiuqing Guo,Jerome I. Rotter,Yii-Der Ida Chen,William E. Kraus,Svati H. Shah,Scott M. Damrauer,Aeron Small,Daniel J. Rader,Anders Berg Wulff,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Anita M. van den Hoek,Hans M.G. Princen,David H. Ledbetter,David J. Carey,John D. Overton,Jeffrey G. Reid,William J. Sasiela,Poulabi Banerjee,Alan R. Shuldiner,Ingrid B. Borecki,Tanya M. Teslovich,George D. Yancopoulos,Scott Mellis,Jesper Gromada,Aris Baras +58 more
TL;DR: Genetic and therapeutic antagonism of ANGPTL3 in humans and of Angptl3 in mice was associated with decreased levels of all three major lipid fractions and decreased odds of atherosclerotic cardiovascular disease.
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Mouse Models for Atherosclerosis and Pharmaceutical Modifiers
Susanne Zadelaar,Robert Kleemann,Lars Verschuren,Jitske de Vries-van der Weij,José W.A. van der Hoorn,Hans M.G. Princen,Teake Kooistra +6 more
TL;DR: The mouse is the most useful, economic, and valid model for studying atherosclerosis and exploring effective therapeutic approaches and the choice of a model should take into account the risk factor to be studied and the working spectrum of the compounds tested.
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Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking.
TL;DR: The effect of ingestion of the antioxidants D,L-alpha-tocopherol (vitamin E) and beta-carotene and of smoking on the resistance of LDL against copper-mediated oxidation and the susceptibility of LDL to lipid peroxidation is examined.
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Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo
Victor W.M. van Hinsbergh,Teake Kooistra,E.A. van den Berg,Hans M.G. Princen,Walter Fiers,J.J. Emeis +5 more
TL;DR: It is most likely that vascular endothelial cells contribute to the increased amount of circulating PAI induced by TNF in vivo, because the number of platelets did not change after TNF injection and the amount of PAI in blood platelets is not sufficient for several hours during an increase in PAI activity.
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Supplementation With Low Doses of Vitamin E Protects LDL From Lipid Peroxidation in Men and Women
Hans M.G. Princen,W. van Duyvenvoorde,R. Buytenhek,A. van der Laarse,G. van Poppel,J.A. Gevers Leuven,Victor W.M. van Hinsbergh +6 more
TL;DR: The minimal supplementary dose of vitamin E necessary to protect LDL against oxidation in vitro was ascertained and the resistance of LDL to oxidation was elevated dose-dependently and differed significantly from the baseline resistance time even after ingestion of only 25 IU/d.