D
David J. Carey
Researcher at Geisinger Health System
Publications - 245
Citations - 17741
David J. Carey is an academic researcher from Geisinger Health System. The author has contributed to research in topics: Schwann cell & Population. The author has an hindex of 67, co-authored 224 publications receiving 14202 citations. Previous affiliations of David J. Carey include Geisinger Medical Center & University of Helsinki.
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Journal ArticleDOI
Syndecans: multifunctional cell-surface co-receptors.
TL;DR: The main function of syndecans appears to be to modulate the ligand-dependent activation of primary signalling receptors at the cell surface, to target the heparan sulphate chains to the appropriate plasma-membrane compartment and to interact with components of the actin-based cytoskeleton.
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The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future
Omri Gottesman,Helena Kuivaniemi,Gerard Tromp,W. Andrew Faucett,Rongling Li,Teri A. Manolio,Saskia C. Sanderson,Joseph L. Kannry,Randi E. Zinberg,Melissa A. Basford,Murray H. Brilliant,David J. Carey,Rex L. Chisholm,Christopher G. Chute,John Connolly,David R. Crosslin,Joshua C. Denny,Carlos J. Gallego,Jonathan L. Haines,Hakon Hakonarson,John B. Harley,Gail P. Jarvik,Isaac S. Kohane,Iftikhar J. Kullo,Eric B. Larson,Catherine A. McCarty,Marylyn D. Ritchie,Dan M. Roden,Maureen E. Smith,Erwin P. Bottinger,Marc S. Williams +30 more
TL;DR: The evolution, accomplishments, opportunities, and challenges of the network are described, from its inception as a five- group consortium focused on genotype–phenotype associations for genomic discovery to its current form as a nine-group consortium pivoting toward the implementation of genomic medicine.
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Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Frederick E. Dewey,Viktoria Gusarova,Richard L Dunbar,Colm O'Dushlaine,Claudia Schurmann,Omri Gottesman,Shane McCarthy,Cristopher V. Van Hout,Shannon Bruse,Hayes Dansky,Joseph B. Leader,Michael F. Murray,Marylyn D. Ritchie,H. Lester Kirchner,Lukas Habegger,Alex Lopez,John Penn,An Zhao,Weiping Shao,Neil Stahl,Andrew J. Murphy,Sara Hamon,Aurelie Bouzelmat,Rick Zhang,Brad Shumel,Robert Pordy,Daniel A. Gipe,Gary Herman,Wayne H-H Sheu,I-Te Lee,I-Te Lee,Kae-Woei Liang,Kae-Woei Liang,Xiuqing Guo,Jerome I. Rotter,Yii-Der Ida Chen,William E. Kraus,Svati H. Shah,Scott M. Damrauer,Aeron Small,Daniel J. Rader,Anders Berg Wulff,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Anita M. van den Hoek,Hans M.G. Princen,David H. Ledbetter,David J. Carey,John D. Overton,Jeffrey G. Reid,William J. Sasiela,Poulabi Banerjee,Alan R. Shuldiner,Ingrid B. Borecki,Tanya M. Teslovich,George D. Yancopoulos,Scott Mellis,Jesper Gromada,Aris Baras +58 more
TL;DR: Genetic and therapeutic antagonism of ANGPTL3 in humans and of Angptl3 in mice was associated with decreased levels of all three major lipid fractions and decreased odds of atherosclerotic cardiovascular disease.
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A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
Noura S. Abul-Husn,Xiping Cheng,Alexander H. Li,Yurong Xin,Claudia Schurmann,Panayiotis Stevis,Yashu Liu,Julia Kozlitina,Stefan Stender,G. Craig Wood,Ann Stepanchick,Matthew D. Still,Shane McCarthy,Colm O'Dushlaine,Jonathan S. Packer,Suganthi Balasubramanian,Nehal Gosalia,David Esopi,Sun Y. Kim,Semanti Mukherjee,Alexander E. Lopez,Erin D. Fuller,John Penn,Xin Chu,Jonathan Z. Luo,Uyenlinh L. Mirshahi,David J. Carey,Christopher D. Still,Michael Feldman,Aeron Small,Scott M. Damrauer,Daniel J. Rader,Brian Zambrowicz,William C. Olson,Andrew J. Murphy,Ingrid B. Borecki,Alan R. Shuldiner,Jeffrey G. Reid,John D. Overton,George D. Yancopoulos,Helen H. Hobbs,Jonathan C. Cohen,Omri Gottesman,Tanya M. Teslovich,Aris Baras,Tooraj Mirshahi,Jesper Gromada,Frederick E. Dewey +47 more
TL;DR: A loss‐of‐function variant in HSD17B13 was associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis.
Journal ArticleDOI
Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
Frederick E. Dewey,Michael F. Murray,John D. Overton,Lukas Habegger,Joseph B. Leader,Samantha N. Fetterolf,Colm O'Dushlaine,Cristopher V. Van Hout,Jeffrey Staples,Claudia Gonzaga-Jauregui,Raghu Metpally,Sarah A. Pendergrass,Monica A. Giovanni,H. Lester Kirchner,Suganthi Balasubramanian,Noura S. Abul-Husn,Dustin N. Hartzel,Daniel R. Lavage,Korey A. Kost,Jonathan S. Packer,Alexander Lopez,John Penn,Semanti Mukherjee,Nehal Gosalia,Manoj Kanagaraj,Alexander H. Li,Lyndon J. Mitnaul,Lance J. Adams,Thomas N. Person,Kavita Praveen,Anthony Marcketta,Matthew S. Lebo,Christina Austin-Tse,Heather Mason-Suares,Shannon Bruse,Scott Mellis,Robert H. Phillips,Neil Stahl,Andrew J. Murphy,Aris N. Economides,Kimberly A. Skelding,Christopher D. Still,James R. Elmore,Ingrid B. Borecki,George D. Yancopoulos,F. Daniel Davis,William A. Faucett,Omri Gottesman,Marylyn D. Ritchie,Alan R. Shuldiner,Jeffrey G. Reid,David H. Ledbetter,Aris Baras,David J. Carey +53 more
TL;DR: Exome-wide association analyses of EHR-derived lipid values, newly implicating rare predicted LoFs, and deleterious missense variants in G6PC in association with triglyceride levels found associations supporting the majority of therapeutic targets for lipid lowering.