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Ingrid B. Borecki
Researcher at Regeneron
Publications - 14
Citations - 2360
Ingrid B. Borecki is an academic researcher from Regeneron. The author has contributed to research in topics: Genome-wide association study & Myeloid. The author has an hindex of 10, co-authored 14 publications receiving 1628 citations. Previous affiliations of Ingrid B. Borecki include Sahlgrenska University Hospital & Washington University in St. Louis.
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Journal ArticleDOI
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Frederick E. Dewey,Viktoria Gusarova,Richard L Dunbar,Colm O'Dushlaine,Claudia Schurmann,Omri Gottesman,Shane McCarthy,Cristopher V. Van Hout,Shannon Bruse,Hayes Dansky,Joseph B. Leader,Michael F. Murray,Marylyn D. Ritchie,H. Lester Kirchner,Lukas Habegger,Alex Lopez,John Penn,An Zhao,Weiping Shao,Neil Stahl,Andrew J. Murphy,Sara Hamon,Aurelie Bouzelmat,Rick Zhang,Brad Shumel,Robert Pordy,Daniel A. Gipe,Gary Herman,Wayne H-H Sheu,I-Te Lee,I-Te Lee,Kae-Woei Liang,Kae-Woei Liang,Xiuqing Guo,Jerome I. Rotter,Yii-Der Ida Chen,William E. Kraus,Svati H. Shah,Scott M. Damrauer,Aeron Small,Daniel J. Rader,Anders Berg Wulff,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Anita M. van den Hoek,Hans M.G. Princen,David H. Ledbetter,David J. Carey,John D. Overton,Jeffrey G. Reid,William J. Sasiela,Poulabi Banerjee,Alan R. Shuldiner,Ingrid B. Borecki,Tanya M. Teslovich,George D. Yancopoulos,Scott Mellis,Jesper Gromada,Aris Baras +58 more
TL;DR: Genetic and therapeutic antagonism of ANGPTL3 in humans and of Angptl3 in mice was associated with decreased levels of all three major lipid fractions and decreased odds of atherosclerotic cardiovascular disease.
Journal ArticleDOI
A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
Noura S. Abul-Husn,Xiping Cheng,Alexander H. Li,Yurong Xin,Claudia Schurmann,Panayiotis Stevis,Yashu Liu,Julia Kozlitina,Stefan Stender,G. Craig Wood,Ann Stepanchick,Matthew D. Still,Shane McCarthy,Colm O'Dushlaine,Jonathan S. Packer,Suganthi Balasubramanian,Nehal Gosalia,David Esopi,Sun Y. Kim,Semanti Mukherjee,Alexander E. Lopez,Erin D. Fuller,John Penn,Xin Chu,Jonathan Z. Luo,Uyenlinh L. Mirshahi,David J. Carey,Christopher D. Still,Michael Feldman,Aeron Small,Scott M. Damrauer,Daniel J. Rader,Brian Zambrowicz,William C. Olson,Andrew J. Murphy,Ingrid B. Borecki,Alan R. Shuldiner,Jeffrey G. Reid,John D. Overton,George D. Yancopoulos,Helen H. Hobbs,Jonathan C. Cohen,Omri Gottesman,Tanya M. Teslovich,Aris Baras,Tooraj Mirshahi,Jesper Gromada,Frederick E. Dewey +47 more
TL;DR: A loss‐of‐function variant in HSD17B13 was associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis.
Journal ArticleDOI
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.
Frederick E. Dewey,Viktoria Gusarova,Colm O'Dushlaine,Omri Gottesman,Jesus A. Trejos,Charleen Hunt,Cristopher V. Van Hout,Lukas Habegger,Buckler David R,Ka Man V. Lai,Joseph B. Leader,Michael F. Murray,Marylyn D. Ritchie,H. Lester Kirchner,David H. Ledbetter,John Penn,Alexander E. Lopez,Ingrid B. Borecki,John D. Overton,Jeffrey G. Reid,David J. Carey,Andrew J. Murphy,George D. Yancopoulos,Aris Baras,Jesper Gromada,Alan R. Shuldiner +25 more
TL;DR: Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers and the inhibition of Angptl4 in mice and monkeys resulted in corresponding reductions in these values.
Journal ArticleDOI
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
Kuan-lin Huang,Edoardo Marcora,Anna A. Pimenova,Antonio Fabio Di Narzo,Manav Kapoor,Sheng Chih Jin,Oscar Harari,Sarah Bertelsen,Benjamin P. Fairfax,Jake Czajkowski,Vincent Chouraki,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Céline Bellenguez,Céline Bellenguez,Yuetiva Deming,Andrew M. McKenzie,Towfique Raj,Alan E. Renton,John P. Budde,Albert V. Smith,Annette L. Fitzpatrick,Joshua C. Bis,Anita L. DeStefano,Hieab H.H. Adams,M. Arfan Ikram,Sven J. van der Lee,Jorge L. Del-Aguila,Maria Victoria Fernandez,Laura Ibanez,Rebecca Sims,Valentina Escott-Price,Richard Mayeux,Jonathan L. Haines,Lindsay A. Farrer,Lindsay A. Farrer,Margaret A. Pericak-Vance,Jean-Charles Lambert,Jean-Charles Lambert,Cornelia M. van Duijn,Lenore J. Launer,Sudha Seshadri,Julie Williams,Philippe Amouyel,Philippe Amouyel,Gerard D. Schellenberg,Bin Zhang,Ingrid B. Borecki,John S. K. Kauwe,Carlos Cruchaga,Ke Hao,Alison Goate +51 more
TL;DR: Results suggest that lower SPI1 expression reduces AD risk by regulating myeloid gene expression and cell function, and experimentally altered PU.1 levels affected the expression of mouse orthologs of many AD risk genes and the phagocytic activity of mouse microglial cells.
Journal ArticleDOI
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Symen Ligthart,Ahmad Vaez,Urmo Võsa,Maria G. Stathopoulou,P. De Vries,Bram P. Prins,P. J. van der Most,Toshiko Tanaka,Elnaz Naderi,Lynda M. Rose,Ying Wu,Robert Karlsson,Maja Barbalić,Honghuang Lin,René Pool,Gu Zhu,Aurélien Macé,C Sidore,Stella Trompet,Massimo Mangino,Maria Sabater-Lleal,John P. Kemp,Ali Abbasi,Tim Kacprowski,Niek Verweij,Albert V. Smith,Tao Huang,Carola Marzi,Mary F. Feitosa,Kurt Lohman,Marcus E. Kleber,Yuri Milaneschi,Christine M. Mueller,M Huq,Efthymia Vlachopoulou,Lyytikäinen L-P.,Christopher Oldmeadow,Joris Deelen,Markus Perola,Jing Hua Zhao,Bjarke Feenstra,Marzyeh Amini,Jari Lahti,Katharina E. Schraut,Myriam Fornage,Bhoom Suktitipat,Chen W-M.,Xiaohui Li,Teresa Nutile,Giovanni Malerba,Jian'an Luan,Tom Bak,Nicholas J. Schork,Elisabeth Thiering,Anubha Mahajan,Riccardo E. Marioni,Evelin Mihailov,Joel Eriksson,Ayse Bilge Ozel,Weihua Zhang,Maria Nethander,Cheng Y-C.,Stella Aslibekyan,Wei Ang,Ilaria Gandin,Loic Yengo,Laura Portas,Charles Kooperberg,Edith Hofer,Kumar B. Rajan,Claudia Schurmann,W. den Hollander,Tarunveer S. Ahluwalia,Jing Zhao,Draisma Hhm.,Ian Ford,Nicholas J. Timpson,Alexander Teumer,Hongyan Huang,Simone Wahl,Yongmei Liu,Jinyan Huang,Uh H-W.,Frank Geller,Peter K. Joshi,Lisa R. Yanek,Elisabetta Trabetti,Benjamin Lehne,Diego Vozzi,M Verbanck,Ginevra Biino,Yasaman Saba,Ingrid Meulenbelt,Jeffery R. O'Connell,Markku Laakso,Franco Giulianini,Magnusson Pke.,Christie M. Ballantyne,J-J Hottenga,Grant W. Montgomery,Fernando Rivadineira,Rico Rueedi,Maristella Steri,Herzig K-H.,David J. Stott,Cristina Menni,Mattias Frånberg,B. St Pourcain,Stephan B. Felix,Tune H. Pers,Bakker Sjl.,Peter Kraft,Annette Peters,Dhananjay Vaidya,Graciela Delgado,Jan H. Smit,V Großmann,Juha Sinisalo,Ilkka Seppälä,Stephen R. Williams,Elizabeth G. Holliday,Matthijs Moed,Claudia Langenberg,Katri Räikkönen,Jun Ding,Harry Campbell,Michèle M. Sale,Chen Y-Di.,Chen Y-Di.,Alan James,Daniela Ruggiero,Nicole Soranzo,Catharina A. Hartman,Erin N. Smith,Gerald S. Berenson,Christian Fuchsberger,Dena G. Hernandez,Tiesler Cmt.,Vilmantas Giedraitis,D C Liewald,Krista Fischer,Dan Mellström,Anders Larsson,Yajuan Wang,William R. Scott,Mattias Lorentzon,John Beilby,Kathleen A. Ryan,Craig E. Pennell,Dragana Vuckovic,Beverley Balkau,Maria Pina Concas,Reinhold Schmidt,C. F. Mendes de Leon,C. F. Mendes de Leon,Erwin P. Bottinger,Margreet Kloppenburg,Lavinia Paternoster,Michael Boehnke,Arthur W. Musk,Gonneke Willemsen,David M. Evans,Madden Paf.,Mika Kähönen,Zoltán Kutalik,Magdalena Zoledziewska,Ville Karhunen,Stephen B. Kritchevsky,Naveed Sattar,Genevieve Lachance,Robert Clarke,T.B. Harris,Olli T. Raitakari,John Attia,D. van Heemst,Eero Kajantie,Rossella Sorice,Giovanni Gambaro,Robert A. Scott,Andrew A. Hicks,Luigi Ferrucci,M. Standl,Cecilia M. Lindgren,John M. Starr,Magnus Karlsson,Lars Lind,Jun Li,John C. Chambers,Trevor A. Mori,de Geus Ejcn.,A. C. Heath,Nicholas G. Martin,Juha Auvinen,Brendan M. Buckley,de Craen Ajm.,M. Waldenberger,Konstantin Strauch,Thomas Meitinger,R. J. Scott,Mark McEvoy,Marian Beekman,Cristina Bombieri,Paul M. Ridker,Karen L. Mohlke,Nancy L. Pedersen,A C Morrison,Dorret I. Boomsma,John Whitfield,David P. Strachan,Albert Hofman,Peter Vollenweider,Francesco Cucca,Jarvelin M-R.,Joop Jukema,Tim D. Spector,Anders Hamsten,Tanja Zeller,André G. Uitterlinden,Matthias Nauck,Vilmundur Gudnason,Lu Qi,H Grallert,Ingrid B. Borecki,Jerome I. Rotter,W. März,Philipp S. Wild,Lokki M-L.,Michael Boyle,Veikko Salomaa,Mads Melbye,Johan G. Eriksson,James F. Wilson,Penninx Bwjh.,Diane M. Becker,B. B. Worrall,Greg Gibson,Ronald M. Krauss,Marina Ciullo,Gianluigi Zaza,Nicholas J. Wareham,Albertine J. Oldehinkel,Lyle J. Palmer,Sarah S. Murray,Peter P. Pramstaller,Stefania Bandinelli,Joachim Heinrich,Erik Ingelsson,Ian J. Deary,Reedik Mägi,Liesbeth Vandenput,P. van der Harst,Karl C. Desch,Jaspal S. Kooner,Claes Ohlsson,Caroline Hayward,Terho Lehtimäki,Alan R. Shuldiner,Donna K. Arnett,Lawrie J. Beilin,Antonietta Robino,Philippe Froguel,Mario Pirastu,T. Jess,Wolfgang Koenig,Loos Rjf.,Denis A. Evans,Helena Schmidt,George Davey Smith,P E Slagboom,Gudny Eiriksdottir,Andrew P. Morris,Bruce M. Psaty,Russel Tracy,Ilja M. Nolte,Eric Boerwinkle,Sophie Visvikis-Siest,Alexander P. Reiner,Myron D. Gross,J. C. Bis,Lude Franke,Oscar H. Franco,E J Benjamin,Daniel I. Chasman,Josée Dupuis,Harold Snieder,Abbas Dehghan,Behrooz Z. Alizadeh +286 more
TL;DR: In this article, the authors performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals.