H
H. Lester Kirchner
Researcher at Geisinger Health System
Publications - 237
Citations - 16340
H. Lester Kirchner is an academic researcher from Geisinger Health System. The author has contributed to research in topics: Population & Retrospective cohort study. The author has an hindex of 63, co-authored 218 publications receiving 13428 citations. Previous affiliations of H. Lester Kirchner include Case Western Reserve University & Boston Children's Hospital.
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Journal ArticleDOI
Association of nocturnal arrhythmias with sleep-disordered breathing: The sleep heart health study
Reena Mehra,Emelia J. Benjamin,Eyal Shahar,Daniel J. Gottlieb,R Nawabit,H. Lester Kirchner,Jayakumar Sahadevan,Susan Redline +7 more
TL;DR: It is postulate that the prevalence of nocturnal cardiac arrhythmias is higher among subjects with than without sleep-disordered breathing, and individuals with severe sleep- disordered breathing have two- to fourfold higher odds of complex arrhythmia development even after adjustment for potential confounders.
Journal ArticleDOI
Prevalence and risk factors for sleep-disordered breathing in 8- to 11-year-old children: association with race and prematurity.
Carol L. Rosen,Emma K. Larkin,H. Lester Kirchner,Judith L. Emancipator,Sarah F. Bivins,Susan Surovec,Richard J. Martin,Susan Redline +7 more
TL;DR: Sleep-disordered breathing is a relatively common condition in 8- to 11-year-old children and potentially vulnerable subgroups, black children, and former preterm infants, are at increased risk.
Journal ArticleDOI
The Effects of Age, Sex, Ethnicity, and Sleep-Disordered Breathing on Sleep Architecture
Susan Redline,H. Lester Kirchner,Stuart F. Quan,Daniel J. Gottlieb,Vishesh K. Kapur,Anne B. Newman +5 more
TL;DR: Men, but not women, show evidence of poorer sleep with aging, suggesting important sex differences in sleep physiology, and sleep architecture varies with sex, age, ethnicity, and SDB.
Journal ArticleDOI
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Frederick E. Dewey,Viktoria Gusarova,Richard L Dunbar,Colm O'Dushlaine,Claudia Schurmann,Omri Gottesman,Shane McCarthy,Cristopher V. Van Hout,Shannon Bruse,Hayes Dansky,Joseph B. Leader,Michael F. Murray,Marylyn D. Ritchie,H. Lester Kirchner,Lukas Habegger,Alex Lopez,John Penn,An Zhao,Weiping Shao,Neil Stahl,Andrew J. Murphy,Sara Hamon,Aurelie Bouzelmat,Rick Zhang,Brad Shumel,Robert Pordy,Daniel A. Gipe,Gary Herman,Wayne H-H Sheu,I-Te Lee,I-Te Lee,Kae-Woei Liang,Kae-Woei Liang,Xiuqing Guo,Jerome I. Rotter,Yii-Der Ida Chen,William E. Kraus,Svati H. Shah,Scott M. Damrauer,Aeron Small,Daniel J. Rader,Anders Berg Wulff,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Anita M. van den Hoek,Hans M.G. Princen,David H. Ledbetter,David J. Carey,John D. Overton,Jeffrey G. Reid,William J. Sasiela,Poulabi Banerjee,Alan R. Shuldiner,Ingrid B. Borecki,Tanya M. Teslovich,George D. Yancopoulos,Scott Mellis,Jesper Gromada,Aris Baras +58 more
TL;DR: Genetic and therapeutic antagonism of ANGPTL3 in humans and of Angptl3 in mice was associated with decreased levels of all three major lipid fractions and decreased odds of atherosclerotic cardiovascular disease.
Journal ArticleDOI
Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
Frederick E. Dewey,Michael F. Murray,John D. Overton,Lukas Habegger,Joseph B. Leader,Samantha N. Fetterolf,Colm O'Dushlaine,Cristopher V. Van Hout,Jeffrey Staples,Claudia Gonzaga-Jauregui,Raghu Metpally,Sarah A. Pendergrass,Monica A. Giovanni,H. Lester Kirchner,Suganthi Balasubramanian,Noura S. Abul-Husn,Dustin N. Hartzel,Daniel R. Lavage,Korey A. Kost,Jonathan S. Packer,Alexander Lopez,John Penn,Semanti Mukherjee,Nehal Gosalia,Manoj Kanagaraj,Alexander H. Li,Lyndon J. Mitnaul,Lance J. Adams,Thomas N. Person,Kavita Praveen,Anthony Marcketta,Matthew S. Lebo,Christina Austin-Tse,Heather Mason-Suares,Shannon Bruse,Scott Mellis,Robert H. Phillips,Neil Stahl,Andrew J. Murphy,Aris N. Economides,Kimberly A. Skelding,Christopher D. Still,James R. Elmore,Ingrid B. Borecki,George D. Yancopoulos,F. Daniel Davis,William A. Faucett,Omri Gottesman,Marylyn D. Ritchie,Alan R. Shuldiner,Jeffrey G. Reid,David H. Ledbetter,Aris Baras,David J. Carey +53 more
TL;DR: Exome-wide association analyses of EHR-derived lipid values, newly implicating rare predicted LoFs, and deleterious missense variants in G6PC in association with triglyceride levels found associations supporting the majority of therapeutic targets for lipid lowering.