H
Harish C. Chandramoorthy
Researcher at King Khalid University
Publications - 55
Citations - 2037
Harish C. Chandramoorthy is an academic researcher from King Khalid University. The author has contributed to research in topics: Medicine & Mesenchymal stem cell. The author has an hindex of 14, co-authored 44 publications receiving 1630 citations. Previous affiliations of Harish C. Chandramoorthy include University of Pittsburgh & Temple University.
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Journal ArticleDOI
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.
Karthik Mallilankaraman,Patrick J. Doonan,César Cárdenas,César Cárdenas,Harish C. Chandramoorthy,Marioly Müller,Russell A. Miller,Nicholas E. Hoffman,Rajesh Kumar Gandhirajan,Jordi Molgó,Morris J. Birnbaum,Brad S. Rothberg,Don-On Daniel Mak,J. Kevin Foskett,Muniswamy Madesh +14 more
TL;DR: The mitochondrial protein MICU1 is demonstrated to be a gatekeeper of MCU-mediated Ca(2+)(m) uptake that is essential to prevent [Ca( 2+)](m) overload and associated stress.
Journal ArticleDOI
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
Karthik Mallilankaraman,César Cárdenas,Patrick J. Doonan,Harish C. Chandramoorthy,Krishna M. Irrinki,Tünde Golenár,György Csordás,Priyanka Madireddi,Jun Yang,Marioly Müller,Russell A. Miller,Jill E. Kolesar,Jordi Molgó,Brett A. Kaufman,György Hajnóczky,J. Kevin Foskett,Muniswamy Madesh +16 more
TL;DR: It is reported that the integral mitochondrial membrane protein MCUR1 (mitochondrial calcium uniporter regulator 1) binds to the MCU and promotes MCU-dependent calcium uptake to control ATP production and autophagy.
Journal ArticleDOI
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.
Rajesh Kumar Gandhirajan,Shu Meng,Harish C. Chandramoorthy,Karthik Mallilankaraman,Salvatore Mancarella,Hui Gao,Roshanak Razmpour,Xiaofeng Yang,Steven R. Houser,Ju Chen,Walter J. Koch,Hong Wang,Jonathan Soboloff,Donald L. Gill,Muniswamy Madesh +14 more
TL;DR: The results indicate that ROS-driven Ca2+ signaling promotes vascular barrier dysfunction and that the SOCe machinery may provide crucial therapeutic targets to limit sepsis-induced ALI.
Journal ArticleDOI
MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity
Nicholas E. Hoffman,Harish C. Chandramoorthy,Harish C. Chandramoorthy,Santhanam Shamugapriya,Xue-Qian Zhang,Sudarsan Rajan,Karthik Mallilankaraman,Rajesh Kumar Gandhirajan,Ronald J. Vagnozzi,Lucas M. Ferrer,Krishnalatha Sreekrishnanilayam,Kalimuthusamy Natarajaseenivasan,Sandhya Vallem,Thomas Force,Eric T. Choi,Joseph Y. Cheung,Muniswamy Madesh +16 more
TL;DR: A molecular mechanism for MICU1 control of MCU-mediated mitochondrial Ca(2+) accumulation is established, and dysregulation of this mechanism probably enhances vascular dysfunction.
Journal ArticleDOI
SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress–mediated cell death
Nicholas E. Hoffman,Harish C. Chandramoorthy,Santhanam Shanmughapriya,Xueqian Q. Zhang,Sandhya Vallem,Patrick J. Doonan,Karthik Malliankaraman,Shuchi Guo,Sudarsan Rajan,John W. Elrod,Walter J. Koch,Joseph Y. Cheung,Muniswamy Madesh +12 more
TL;DR: In this paper, the authors showed that SLC25A23 plays an important role in mitochondrial matrix Ca2+ influx and showed that the SLC 25A23 knockdown lowers basal mROS accumulation, attenuates oxidant-induced ATP decline, and reduces cell death.