H
Hayk Hovhannisyan
Researcher at University of Massachusetts Medical School
Publications - 12
Citations - 1544
Hayk Hovhannisyan is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Histone code & Chromatin immunoprecipitation. The author has an hindex of 7, co-authored 12 publications receiving 1414 citations. Previous affiliations of Hayk Hovhannisyan include University of Massachusetts Amherst.
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Journal ArticleDOI
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Tripti Gaur,Christopher J. Lengner,Hayk Hovhannisyan,Ramesh A. Bhat,Peter V.N. Bodine,Barry S. Komm,Amjad Javed,Andre J. van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +10 more
TL;DR: It is proposed that WNT/TCF1 signaling, like bone morphogenetic protein/transforming growth factor-β signaling, activates Runx2 gene expression in mesenchymal cells for the control of osteoblast differentiation and skeletal development.
Journal ArticleDOI
The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in Osteoblasts
Mario Galindo,Jitesh Pratap,Daniel W. Young,Hayk Hovhannisyan,Hee Jeong Im,Je-Yong Choi,Jane B. Lian,Janet L. Stein,Gary S. Stein,Andre J. Van Wijnen +9 more
TL;DR: It is proposed that Runx2 levels and function are biologically linked to a cell growth-related G1 transition in osteoblastic cells.
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Transcriptional Induction of the Osteocalcin Gene During Osteoblast Differentiation Involves Acetylation of Histones H3 and H4
Jiali Shen,Hayk Hovhannisyan,Jane B. Lian,Martin Montecino,Gary S. Stein,Janet L. Stein,Andre J. Van Wijnen +6 more
TL;DR: It is concluded that acetylation of histones H3 and H4 is functionally coupled to the chromatin remodeling events that mediate the developmental induction of OC gene transcription in bone cells.
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Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase
Partha Mitra,Rong Lin Xie,Ricardo F. Medina,Hayk Hovhannisyan,S. Kaleem Zaidi,Yue Wei,J. Wade Harper,Janet L. Stein,Andre J. Van Wijnen,Gary S. Stein +9 more
TL;DR: The results establish that HiNF-P is the ultimate link in a linear signaling pathway that is initiated with the growth factor-dependent induction of cyclin E/CDK2 kinase activity at the restriction point and culminates in the activation of histone H4 genes through Hi NF-P at the G1/S phase transition.
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Functional characterization of a human histone gene cluster duplication
TL;DR: A genomic duplication of the human histone gene cluster located at chromosome 1q21 is described, which effectively doubles the previously known size and gene number of that cluster.