H
Hayley H. A. Thorpe
Researcher at University of Guelph
Publications - 13
Citations - 140
Hayley H. A. Thorpe is an academic researcher from University of Guelph. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 8 publications receiving 46 citations.
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Journal ArticleDOI
Adolescent neurodevelopment and substance use: Receptor expression and behavioral consequences
TL;DR: The current review provides an in-depth overview and update of the developmental changes in neurotransmission during adolescence, as well as the impact of drug exposure during this neurodevelopmental window.
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Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates
TL;DR: This review focuses on the neurobiological divergences associated with adolescent substance use, derived from a cross-sectional, retrospective, and longitudinal studies, and highlights how the use of these substances during adolescence may relate to behavioral and neuroimaging-based outcomes.
Journal ArticleDOI
A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models
Catharine A. Mielnik,Kim S. Sugamori,David B. Finlay,Hayley H. A. Thorpe,Matthieu Schapira,Nirunthan Sivananthan,Chun Kit Li,Vincent M. Lam,Sean Harrington,Mostafa H. Abdelrahman,Laurent Trembleau,W. McIntyre Burnham,Jibran Y. Khokhar,Ali Salahpour,Amy J. Ramsey,Michelle Glass,Iain R. Greig,Ruth A. Ross +17 more
TL;DR: ABM300 decreased novelty-induced hyperactivity, exaggerated stereotypy, and vertical exploration in both transgenic models of hyperdopaminergia, as well as normalizing PPI in DATKO mice, warranting further investigation as a potential therapeutic target in psychiatry.
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Intermittent cold exposure improves glucose homeostasis despite exacerbating diet-induced obesity in mice housed at thermoneutrality.
Greg L. McKie,Hesham Shamshoum,Kristin Hunt,Hayley H. A. Thorpe,Hana A. Dibe,Jibran Y. Khokhar,Christine A. Doucette,David C. Wright +7 more
TL;DR: McKie et al. as discussed by the authors showed that ICE increased serum concentrations of insulin and C-peptide in response to glucose, suggesting that ICE may improve glucose tolerance by potentiating pancreatic glucose-stimulated insulin secretion.
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High genes: Genetic underpinnings of cannabis use phenotypes.
TL;DR: Delineating genetic risk factors in the various stages of cannabis use will provide insight into the biological mechanisms related to cannabis use, and highlight points of intervention prior to and following the development of dependence, as well as identify targets to aid drug development for treating problematic cannabis use.