H
Heather Hampel
Researcher at Ohio State University
Publications - 258
Citations - 21694
Heather Hampel is an academic researcher from Ohio State University. The author has contributed to research in topics: Lynch syndrome & Cancer. The author has an hindex of 65, co-authored 210 publications receiving 18316 citations. Previous affiliations of Heather Hampel include The Ohio State University Wexner Medical Center & Dana Corporation.
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Journal ArticleDOI
Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer).
Heather Hampel,Wendy L. Frankel,Edward W. Martin,Mark Arnold,Karamjit S. Khanduja,Philip Kuebler,Hidewaki Nakagawa,Kaisa Sotamaa,Thomas W. Prior,Judith A. Westman,Jenny Panescu,Dan Fix,Janet Lockman,Ilene Comeras,Albert de la Chapelle +14 more
TL;DR: Routine molecular screening of patients with colorectal adenocarcinoma for the Lynch syndrome identified mutations in patients and their family members that otherwise would not have been detected.
Journal ArticleDOI
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
Sapna Syngal,Randall E. Brand,James M. Church,Francis M. Giardiello,Heather Hampel,Randall W. Burt +5 more
TL;DR: Patients who meet clinical criteria for a syndrome as well as those with identified pathogenic germline mutations should receive appropriate surveillance measures in order to minimize their overall risk of developing syndrome-specific cancers.
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American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility
Mark E. Robson,Mark E. Robson,Angela R. Bradbury,Banu Arun,Susan M. Domchek,James M. Ford,Heather Hampel,Stephen M. Lipkin,Sapna Syngal,Dana S. Wollins,Noralane M. Lindor +10 more
TL;DR: This statement makes recommendations in the following areas: germline implications of somatic mutation profiling, multigene panel testing for cancer susceptibility, quality assurance in genetic testing, education of oncology professionals, and access to cancer genetic services.
Journal ArticleDOI
Feasibility of screening for Lynch syndrome among patients with colorectal cancer.
Heather Hampel,Wendy L. Frankel,Edward W. Martin,Mark Arnold,Karamjit S. Khanduja,Philip Kuebler,Mark Clendenning,Kaisa Sotamaa,Thomas W. Prior,Judith A. Westman,Jenny Panescu,Dan Fix,Janet Lockman,Jennifer LaJeunesse,Ilene Comeras,Albert de la Chapelle +15 more
TL;DR: One of every 35 patients with CRC has LS, and each has at least three relatives with LS; all of whom can benefit from increased cancer surveillance, but IHC is more readily available and helps to direct gene testing.
Journal ArticleDOI
Genetic/familial high-risk assessment: breast and ovarian.
Mary B. Daly,Jennifer E. Axilbund,Saundra S. Buys,Beth Crawford,Carolyn Farrell,Susan Friedman,Judy Garber,Salil Goorha,Stephen B. Gruber,Heather Hampel,Virginia Kaklamani,Wendy Kohlmann,Allison W. Kurian,Jennifer K. Litton,P. Kelly Marcom,Robert L. Nussbaum,Kenneth Offit,Tuya Pal,Boris Pasche,Robert Pilarski,Gwen Reiser,Kristen M. Shannon,Jeffrey R. Smith,Elizabeth M. Swisher,Jeffrey N. Weitzel +24 more
TL;DR: Overview All cancers develop as a result of mutations in certain genes, such as those involved in the regulation of cell growth and/or DNA repair, but not all of these mutations are inherited from a parent.