Heidi W. Thermenos

TL;DR: Among patients, the magnitude of MPFC task suppression negatively correlated with default connectivity, suggesting an association between the hyperactivation and hyperconnectivity in schizophrenia.

TL;DR: The results did not indicate lateralized heritability differences or greater genetic influences on the size of regions underlying higher cognitive functions, which provides key information for imaging genetic studies and other studies of brain phenotypes and endophenotypes.

TL;DR: The limited effects of site and scanner manufacturer support the use of multisite studies, such as NAPLS, as a viable means of collecting data on rare populations and increasing power in univariate functional connectivity studies, however, the results indicate that aggregation of fcMRI data across longer scan durations is necessary to increase the reliability of connectivity estimates at the single‐subject level.

TL;DR: It is discovered that increased neural connectivity in the cerebello-thalamo-cortical circuitry predicts psychosis in those at high risk, and is present in people with schizophrenia.

TL;DR: These results provide strong evidence of regionally specific patterns rather than a single, global genetic factor in cortical thickness, which can serve as a step toward identifying novel phenotypes for genetic association studies of psychiatric disorders and normal and pathological cognitive aging.