H
Heidrun Potschka
Researcher at Ludwig Maximilian University of Munich
Publications - 218
Citations - 10984
Heidrun Potschka is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Epilepsy & Status epilepticus. The author has an hindex of 51, co-authored 194 publications receiving 9701 citations. Previous affiliations of Heidrun Potschka include University of Giessen & University of Veterinary Medicine Hanover.
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Journal ArticleDOI
Drug resistance in brain diseases and the role of drug efflux transporters
TL;DR: There is increasing evidence that drug efflux transporters have an important role in drug-resistant brain disorders, and this information should allow more efficacious treatment strategies to be developed.
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Blood-Brain Barrier Active Efflux Transporters: ATP-Binding Cassette Gene Family
TL;DR: Modulation of ABC efflux transporters at the BBB forms a novel strategy to enhance the penetration of drugs into the brain and may yield new therapeutic options for drug-resistant CNS diseases.
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Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
TL;DR: Transporter characteristics for drug efflux transport systems identified in the blood-brain barrier and blood-cerebrospinal fluid (CSF) barrier are summarized to summarize strategies for modulating or by-passingDrug efflux transporters at the BBB as novel therapeutic approaches to drug-resistant brain diseases.
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Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic Drugs
TL;DR: This work argues against epilepsy-induced alterations in specific drug targets as a major cause of pharmacoresistant epilepsy, but rather points to nonspecific and possibly adaptive mechanisms, such as decreased drug uptake into the brain by intrinsic or acquired over-expression of multidrug transporters in the blood-brain barrier (BBB).
Journal ArticleDOI
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.
Wilko D. Altrock,Susanne tom Dieck,Susanne tom Dieck,Maxim Sokolov,Alexander C. Meyer,Albrecht Sigler,Cord Brakebusch,Reinhard Fässler,Karin Richter,Tobias M. Boeckers,Tobias M. Boeckers,Heidrun Potschka,Claudia Brandt,Wolfgang Löscher,Dörte Grimberg,Thomas Dresbach,Anne Hempelmann,Hadir Hassan,Detlef Balschun,Julietta U. Frey,Johann Helmut Brandstätter,Craig C. Garner,Christian Rosenmund,Eckart D. Gundelfinger +23 more
TL;DR: It is shown that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses.