Heike Beck

TL;DR: It is demonstrated that ferroptosis is a pervasive and dynamic form of cell death, which, when impeded, promises substantial cytoprotection.

TL;DR: It is concluded that TrxR2 plays a pivotal role in both hematopoiesis and heart function and the contribution of individual enzymes to the redox metabolism in different cell types is known.

TL;DR: The knowledge of molecular mechanisms of angiogenesis following cerebral ischemia is summarized and experimental pharmacological and cellular approaches to stimulate and enhance post-ischemicAngiogenesis are discussed.

TL;DR: The spatial and temporal correlation between the induction of angiogenesis with V EGF and VEGFR-1 expression suggests that the ischemic upregulation of VEGF represents a physiological response of the brain to counterbalance hypoxia/ischemia in order to protect neuroectodermal tissue.

TL;DR: It is demonstrated that VEGF, via local secretion by neural progenitors, induces brain angiogenesis and guides the growth of capillaries toward the ventricular zone and establishes the critical importance of neuroectoderm-derived V EGF in the morphogenesis of the brain.