S
Sho Kobayashi
Researcher at Yamagata University
Publications - 51
Citations - 4353
Sho Kobayashi is an academic researcher from Yamagata University. The author has contributed to research in topics: Glutathione & Chemistry. The author has an hindex of 12, co-authored 39 publications receiving 2262 citations.
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Journal ArticleDOI
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
José Pedro Friedmann Angeli,Manuela Schneider,Bettina Proneth,Yulia Y. Tyurina,Vladimir A. Tyurin,Victoria Jayne Hammond,Nadja Herbach,Michaela Aichler,Axel Walch,E. Eggenhofer,Devaraj Basavarajappa,Olof Rådmark,Sho Kobayashi,Tobias Seibt,Heike Beck,Frauke Neff,Irene Esposito,Rüdiger Wanke,Heidi Förster,Olena Yefremova,Marc Heinrichmeyer,Georg W. Bornkamm,Edward K. Geissler,Stephen B. Thomas,Brent R. Stockwell,Valerie B. O'Donnell,Valerian E. Kagan,Joel A. Schick,Marcus Conrad +28 more
TL;DR: It is demonstrated that ferroptosis is a pervasive and dynamic form of cell death, which, when impeded, promises substantial cytoprotection.
Journal ArticleDOI
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Sebastian Doll,Bettina Proneth,Yulia Y. Tyurina,Elena Panzilius,Sho Kobayashi,Irina Ingold,Martin Irmler,Johannes Beckers,Michaela Aichler,Axel Walch,Holger Prokisch,Dietrich Trümbach,Gaowei Mao,Feng Qu,Hülya Bayır,Joachim Füllekrug,Christina Scheel,Wolfgang Wurst,Joel A. Schick,Valerian E. Kagan,José Pedro Friedmann Angeli,Marcus Conrad +21 more
TL;DR: Pharmacological targeting of ACSL4 with thiazolidinediones, a class of antidiabetic compound, ameliorated tissue demise in a mouse model of ferroptosis, suggesting that ACSL 4 inhibition is a viable therapeutic approach to preventing ferroPTosis-related diseases.
Journal ArticleDOI
The ferroptosis inducer erastin irreversibly inhibits system x c − and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
Mami Sato,Ryosuke Kusumi,Shinji Hamashima,Sho Kobayashi,Satoru Sasaki,Yuhei Komiyama,Takuji Izumikawa,Marcus Conrad,Shiro Bannai,Hideyo Sato +9 more
TL;DR: It is suggested that only a very short pre-treatment of erastin suffices to synergize with cisplatin to efficiently induce cancer cell death, findings that might guide the design of novel cancer treatment paradigms.
Journal ArticleDOI
Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.
Ann Massie,Anneleen Schallier,Seong Woong Kim,Ruani N Fernando,Sho Kobayashi,Heike Beck,Dimitri De Bundel,Katia Vermoesen,Shiro Bannai,Ilse Julia Smolders,Marcus Conrad,Nikolaus Plesnila,Hideyo Sato,Yvette Michotte +13 more
TL;DR: The current data point toward system xc˜ as a possible target for the development of new pharmacotherapies for the treatment of PD and emphasize the need to continue the search for specific ligands for system xC˜.
Journal ArticleDOI
Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter IMPLICATIONS FOR IMMUNE FUNCTION
Sho Kobayashi,Mami Sato,Takayuki Kasakoshi,Takumi Tsutsui,Masahiro Sugimoto,Mitsuhiko Osaki,Futoshi Okada,Kiharu Igarashi,Jun Hiratake,Takujiro Homma,Marcus Conrad,Junichi Fujii,Tomoyoshi Soga,Shiro Bannai,Hideyo Sato +14 more
TL;DR: It is concluded that cystathionine is a novel physiological substrate of system xc− and that the accumulation of cystATHionine in immune tissues is exclusively mediated by system x c−.