H
Helen Kim
Researcher at University of Alabama at Birmingham
Publications - 55
Citations - 2798
Helen Kim is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Grape seed extract & Proteomics. The author has an hindex of 27, co-authored 55 publications receiving 2675 citations.
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Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways
TL;DR: Preliminary results of studies in patients with hereditary hemorrhagic telangiectasia in which several patients had dramatic attenuation of their symptoms after 1 wk of ingesting soy-based beverages suggest that the mechanism of genistein involves, if not requires, TGFbeta1-signaling.
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High throughput two‐dimensional blue‐native electrophoresis: A tool for functional proteomics of mitochondria and signaling complexes
Paul S. Brookes,Anita Pinner,Anup Ramachandran,Lori Coward,Stephen Barnes,Helen Kim,Victor M. Darley-Usmar +6 more
TL;DR: 2‐D blue‐native gel electrophoresis was applied to the mitochondrial proteome and by coupling to tryptic peptide fingerprinting using matrix‐assisted laser desorption/ionization‐time of flight mass spectrometry, a partial mitochondrial proteomes map has been assembled.
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Modification of the Mitochondrial Proteome in Response to the Stress of Ethanol-dependent Hepatotoxicity
Aparna Venkatraman,Aimee Landar,Ashley J. Davis,Laura Chamlee,Todd Sanderson,Helen Kim,Grier P. Page,Melissa Pompilius,Scott W. Ballinger,Victor M. Darley-Usmar,Shannon M. Bailey +10 more
TL;DR: It is demonstrated that chronic ethanol consumption extends to a modification of the mitochondrial proteome far broader than realized previously and suggests that the response of mitochondria to stress may not involve non-discriminate changes in the proteome but is restricted to those metabolic pathways that have a direct role in a specific pathology.
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Simvastatin enhances learning and memory independent of amyloid load in mice
TL;DR: Whether administering a statin drug (simvastatin) would protect against the development of behavioral deficits in an established mouse model of Alzheimer's disease is determined.
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Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity
Huang-Ge Zhang,Helen Kim,Cunren Liu,Shaohua Yu,Jianhua Wang,William E. Grizzle,Robert P. Kimberly,Stephen Barnes +7 more
TL;DR: Data suggest that partial reversal of tumor exosome-mediated inhibition of NK cell tumor cytotoxicity may account for the anti-cancer properties of curcumin.