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Shaohua Yu
Researcher at University of Alabama at Birmingham
Publications - 17
Citations - 2219
Shaohua Yu is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Microvesicles & T cell. The author has an hindex of 13, co-authored 17 publications receiving 1992 citations. Previous affiliations of Shaohua Yu include University of Alabama.
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Journal ArticleDOI
Murine Mammary Carcinoma Exosomes Promote Tumor Growth by Suppression of NK Cell Function
Cunren Liu,Shaohua Yu,Kurt R. Zinn,Jianhua Wang,Liming Zhang,Yujiang Jia,John C. Kappes,Stephen Barnes,Robert P. Kimberly,William E. Grizzle,Huang-Ge Zhang,Huang-Ge Zhang +11 more
TL;DR: It is proposed that tumor exosomes contribute to the growth of tumors by blocking IL-2-mediated activation of NK cells and their cytotoxic response to tumor cells.
Journal ArticleDOI
Tumor Exosomes Inhibit Differentiation of Bone Marrow Dendritic Cells
Shaohua Yu,Cunren Liu,Kaihong Su,Jianhua Wang,Yuelong Liu,Liming Zhang,Chuanyu Li,Yingzi Cong,Robert P. Kimberly,William E. Grizzle,Carla I. Falkson,Huang-Ge Zhang,Huang-Ge Zhang +12 more
TL;DR: It is demonstrated that TS/A exosomes block the differentiation of murine myeloid precursor cells into dendritic cells (DC) in vitro, and data suggest that tumor exosome-mediated induction of IL-6 plays a role in blocking BM DC differentiation.
Journal ArticleDOI
Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host
Cunren Liu,Shaohua Yu,John C. Kappes,Jianhua Wang,William E. Grizzle,Kurt R. Zinn,Huang-Ge Zhang,Huang-Ge Zhang +7 more
TL;DR: In vivo imaging analysis and Western blot analyses suggest that MSCs suppress IL-2-mediated NK cell cytotoxicity by affecting the activity of Stat5 and fluorescence-activated cell sorter analysis of the composition of lung leukocytes indicates that the removal of tumors also leads to the reduction of M SCs accumulated in the lung.
Journal Article
Expansion of Spleen Myeloid Suppressor Cells Represses NK Cell Cytotoxicity in Tumor Bearing Host
Cunren Liu,Shaohua Yu,Kurt R. Zinn,Jianhua Wang,William E. Grizzle,John C. Kappes,Huang-Ge Zhang +6 more
Journal ArticleDOI
A Membrane Form of TNF-α Presented by Exosomes Delays T Cell Activation-Induced Cell Death
Huang-Ge Zhang,Huang-Ge Zhang,Cunren Liu,Kaihong Su,Shaohua Yu,Liming Zhang,Shuangqin Zhang,Jianhua Wang,Xu Cao,William E. Grizzle,Robert P. Kimberly +10 more
TL;DR: It is shown that the exosomes produced by synovial fibroblasts obtained from individuals with rheumatoid arthritis (RASF) contain a membrane bound form of TNF-α, which is effectively taken up by anti-CD3-activated T cells, activated AKT and NF-κB and rendered these activated T cells resistant to apoptosis.