Ting-Jan Cho

TL;DR: It is proposed that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner’s syndrome and in phenotypic differences between the sexes in health and disease.

TL;DR: This article reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes, and concluded that the gene content of Y chromosome became specialized through selection to maintain the ancestral dosage of homologous X-Y gene pairs that function as broadly expressed regulators of transcription, translation and protein stability.

TL;DR: An empirical reconstruction of human MSY evolution is presented, in which each stratum transitioned from rapid, exponential loss of ancestral genes to strict conservation through purifying selection.

TL;DR: Using super-resolution sequencing, the Y Chromosome of Bos taurus (bull) is explored and is found to be dominated by massive, lineage-specific amplification of testis-expressed gene families, making it the most gene-dense Y chromosome sequenced to date.

TL;DR: N nanopore sequencing is applied in search of the site of integration of Tg(Pou5f1-EGFP)2Mnn (also known as Oct4:EGFP), a widely used fluorescent reporter in mouse germ line research, and it is suggested that such an approach provides a rapid, cost-effective method for identifying and analyzing transgene integration sites.