Helena Kiefel

TL;DR: This work identifies capillary and HEV markers and candidate mechanisms for regulated recruitment of lymphocytes, including a lymph node HEV–selective transmembrane mucin; transcriptional control of functionally specialized carbohydrate ligands for lymphocyte L-selectin; and metabolic programs for lipid mediators of lymphocyte motility and chemotaxis.

TL;DR: The authors profile murine BECs from peripheral lymph nodes by single cell analysis and identify subsets of cells specialised for immune cell recruitment and vascular homeostasis, including a medullary venous population whose gene signature predicts a selective role in myeloid cell (vs lymphocyte) recruitment to the medulla.

TL;DR: Results revealed localized vascular expression of FVIII and von Willebrand factor and identified LECs as a major cellular source of F VIII in extrahepatic tissues.

TL;DR: A single cell atlas provides a molecular blueprint of the lymph node blood vasculature and defines subset specialization for immune cell recruitment and vascular homeostasis and identifies multiple novel subsets.