Paul Kubes

TL;DR: It is demonstrated that an S. aureus breach across skin leads to some migration of the pathogen to the draining lymph node, but no further, and after infection, neutrophils were almost immediately recruited to the lymph nodes via specialized blood vessels to cut bacteria off at the pass.

TL;DR: The authors profile murine BECs from peripheral lymph nodes by single cell analysis and identify subsets of cells specialised for immune cell recruitment and vascular homeostasis, including a medullary venous population whose gene signature predicts a selective role in myeloid cell (vs lymphocyte) recruitment to the medulla.

TL;DR: It is indicated that GATA6+ macrophages within the peritoneal cavity are a conduit of dissemination for i.v. S. aureus, and changing the route of antibiotic delivery could provide a more effective treatment for patients with peritonitis-associated bacterial sepsis.

TL;DR: The capacity of neutrophils to recirculate is established, much like lymphocytes via L-selectin and high endothelial venules in lymph nodes, and it is demonstrated how the presence of neutophils at steady state fortifies the lymph node in case of an infection disseminating through lymphatics.

TL;DR: It is shown that pairs of neutrophils arriving closely one after another at capillary bifurcations migrate to alternating branches in vivo and in vitro, and the effect of inter-neutrophil interactions during migration on overall lymphocyte trafficking patterns in confined environments is outlined.