H
Helena Shiels
Researcher at University of Chicago
Publications - 3
Citations - 1654
Helena Shiels is an academic researcher from University of Chicago. The author has contributed to research in topics: Antigen & CD28. The author has an hindex of 3, co-authored 3 publications receiving 1588 citations. Previous affiliations of Helena Shiels include Howard Hughes Medical Institute.
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Journal ArticleDOI
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
Tullia Lindsten,Andrea J. Ross,Ayala King,Wei-Xing Zong,Jeffrey C. Rathmell,Helena Shiels,Eugen Ulrich,Katrina G. Waymire,Patryce L. Mahar,Kenneth A. Frauwirth,Yifeng Chen,Michael C. Wei,Vicki M. Eng,David M. Adelman,M. Celeste Simon,Averil Ma,Jeffrey A. Golden,Gerard I. Evan,Stanley J. Korsmeyer,Grant R. MacGregor,Craig B. Thompson +20 more
TL;DR: Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis and are found to be developmentally normal and reproductively fit.
Journal Article
Expression and Function of CTLA-4 in Th1 and Th2 Cells
TL;DR: It is concluded that CTLA-4 can function to suppress the production of cytokines produced by both Th1 and Th2 cells.
Journal ArticleDOI
TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs
Helena Shiels,Xiantang Li,Paul T. Schumacker,Emin Maltepe,Emin Maltepe,Philip Padrid,Anne I. Sperling,Craig B. Thompson,Tullia Lindsten +8 more
TL;DR: In this paper, the authors demonstrate that TRAF4 is required to regulate the anastomosis of the upper and lower respiratory systems during development, and that lack of TRAF 4 expression results in a localized, developmental defect of upper respiratory tract.