E
Eugen Ulrich
Researcher at University of California, San Francisco
Publications - 5
Citations - 2690
Eugen Ulrich is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Signal transduction & Protein kinase B. The author has an hindex of 4, co-authored 5 publications receiving 2619 citations. Previous affiliations of Eugen Ulrich include Lincoln's Inn.
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Journal ArticleDOI
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
Tullia Lindsten,Andrea J. Ross,Ayala King,Wei-Xing Zong,Jeffrey C. Rathmell,Helena Shiels,Eugen Ulrich,Katrina G. Waymire,Patryce L. Mahar,Kenneth A. Frauwirth,Yifeng Chen,Michael C. Wei,Vicki M. Eng,David M. Adelman,M. Celeste Simon,Averil Ma,Jeffrey A. Golden,Gerard I. Evan,Stanley J. Korsmeyer,Grant R. MacGregor,Craig B. Thompson +20 more
TL;DR: Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis and are found to be developmentally normal and reproductively fit.
Journal ArticleDOI
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
Andrea Kauffmann-Zeh,Pablo Rodriguez-Viciana,Eugen Ulrich,Christopher C. Gilbert,Paul J. Coffer,Julian Downward,Gerard I. Evan +6 more
TL;DR: It is shown that Ras activation of PI(3)K suppresses c-Myc-induced apoptosis through the activation of PKB/Akt but not p70S6K, and that Ras is an effective promoter of apoptosis, through the Raf pathway, which activates contradictory intracellular pathways that modulate cell viability.
Journal ArticleDOI
Specific TrkA survival signals interfere with different apoptotic pathways
Eugen Ulrich,Annette Duwel,Andrea Kauffmann-Zeh,Christopher C. Gilbert,Debbie Lyon,Brian B. Rudkin,Gerard I. Evan,Dionisio Martin-Zanca +7 more
TL;DR: It is shown that the Akt/PKB pathway is essential for NGF stimulated TrkA survival signalling in the case of U.V.-induced apoptosis, but that apoptosis induced by c-Myc is also blocked by a novel, Akt-PKB-independent, pathway.
Journal ArticleDOI
Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic Bcl-2 family member.
Eugen Ulrich,Andrea Kauffmann-Zeh,Anne-Odile Hueber,Jill Williamson,Thomas Chittenden,Averil Ma,Gerard I. Evan +6 more
TL;DR: To facilitate the creation of Bak knockout mice and the further analysis of this Bcl-2 family member, the complete mouse Bak cDNA is isolated and sequenced and the murine bak gene is mapped.
Book ChapterDOI
The Integration of Signalling Pathways in Mammalian Cells
Gerard I. Evan,Andrea Kauffmann-Zeh,Eugen Ulrich,Trevor D. Littlewood,David C. Hancock,Elizabeth Harrington +5 more
TL;DR: As the human body comprises some ten thousand billion cells, that undergo a total of some 1016 cell divisions during the course of a human life, the cancer cell becomes extremely rare.