H
Helge Ewers
Researcher at Free University of Berlin
Publications - 87
Citations - 5053
Helge Ewers is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Microscopy & Super-resolution microscopy. The author has an hindex of 29, co-authored 75 publications receiving 4255 citations. Previous affiliations of Helge Ewers include École Polytechnique Fédérale de Lausanne & King's College London.
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Endosome dysfunction leads to gain-of-function TLR7 and human lupus
Harshita Mishra,Ee Lyn Lim,Oliver Thieck,Thomas Magg,Johannes Raedler,Christiane Wolf,Christoph Klein,Helge Ewers,Min Ae Lee-Kirsch,David Meierhofer,Fabian Hauck,Olivia Majer +11 more
TL;DR: In this article , the authors show that a dysregulated endosomal compartment leads to unrestricted TLR7 signaling and human lupus, and that an amino acid insertion in UNC93B1 in a patient with childhood-onset Lupus leads to an increase in endocytosis, which reduces the interaction with the BORC-Arl8b complex.
Journal ArticleDOI
Segmentation of Membrane Protein Motion in the Axon Initial Segment
TL;DR: It is found that the lateral motion of membrane molecules becomes reduced in the AIS during development and that this reduction correlates with cytoskeletal organization into ring-like structures.
Journal ArticleDOI
Actin rings form plasma membrane diffusion barriers.
Jakob Rentsch,Batuhan Sezen,Selle Bandstra,Alena Bresch,Jia Hui Li,Francesca Bottanelli,Helge Ewers +6 more
TL;DR: In this article , the authors show that the axon initial segment (AIS) is caused by the actin cytoskeleton, and they combine in silico experiments with high-speed, high-density single-particle tracking and superresolution microscopy.
Posted ContentDOI
An efficient GUI-based clustering software for simulation and Bayesian cluster analysis of single-molecule localization microscopy data
Saskia Kutz,Ando C. Zehrer,Roman Svetlitckii,Gülce S. Gülcüler Balta,Lucrezia Galli,Susanne Kleber,Ana Martin-Villalba,Helge Ewers +7 more
TL;DR: In this paper, the authors combine single-molecule fluorescence microscopy with cluster algorithms that can reliably and reproducibly distinguish clusters from fluctuations in the background noise to generate quantitative data on this complex process.
Journal ArticleDOI
Optogenetic delivery of single molecules to the plasma membrane
TL;DR: In this paper , single molecule microscopy is used for the investigation of functional events at the plasma membrane, changes is membrane mobility can be correlated to cellular events or structures and offer quantitative data that from ensemble methods is impossible to yield.