H
Helge Ewers
Researcher at Free University of Berlin
Publications - 87
Citations - 5053
Helge Ewers is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Microscopy & Super-resolution microscopy. The author has an hindex of 29, co-authored 75 publications receiving 4255 citations. Previous affiliations of Helge Ewers include École Polytechnique Fédérale de Lausanne & King's College London.
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Journal ArticleDOI
High-speed single-particle tracking of GM1 in model membranes reveals anomalous diffusion due to interleaflet coupling and molecular pinning.
Katelyn M. Spillane,Jaime Ortega-Arroyo,Gabrielle de Wit,Christian Eggeling,Helge Ewers,Mark I. Wallace,Philipp Kukura +6 more
TL;DR: It is shown that molecular pinning and interleaflet coupling between lipid tail domains on a nanoscopic scale suffice to induce transient immobilization and thereby anomalous subdiffusion on the millisecond time scale.
Journal ArticleDOI
Nanoscopic compartmentalization of membrane protein motion at the axon initial segment.
David Albrecht,David Albrecht,David Albrecht,Christian M. Winterflood,Christian M. Winterflood,Mohsen Sadeghi,Thomas Tschager,Frank Noé,Helge Ewers,Helge Ewers,Helge Ewers +10 more
TL;DR: A new mechanistic model for the AIS diffusion barrier is proposed using single-particle tracking time course experiments and it is shown that the mobility of lipid-anchored molecules in the A IS is enriched in specific molecules.
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Unblending of transcriptional condensates in human repeat expansion disease
Shaon Basu,Sebastian D. Mackowiak,Henri Niskanen,Dora Knezevic,Vahid Asimi,Stefanie Grosswendt,Hylkje Geertsema,Salaheddine Ali,Salaheddine Ali,Ivana Jerković,Helge Ewers,Stefan Mundlos,Stefan Mundlos,Alexander Meissner,Alexander Meissner,Alexander Meissner,Daniel M. Ibrahim,Daniel M. Ibrahim,Denes Hnisz +18 more
TL;DR: A molecular classification of TF IDRs is presented, which provides a framework to dissect TF function in diseases associated with transcriptional dysregulation and suggests that unblending of transcriptional condensates may underlie human pathologies.
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A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks
TL;DR: It is found that, during development, a marker of the septin complex, Septin7 (Sept7), becomes localized to the spine neck where it forms a stable structure underneath the plasma membrane, which indicates that Sept7 regulates membrane protein access to spines.
Journal ArticleDOI
Label-Free Optical Detection and Tracking of Single Virions Bound to Their Receptors in Supported Membrane Bilayers
Helge Ewers,Volker Jacobsen,Enrico Klotzsch,Alicia E. Smith,and Ari Helenius,Vahid Sandoghdar +5 more
TL;DR: An interferometric optical detection scheme is applied to image and track unlabeled single virions and promises to be generally applicable to studying the motion of unlabeling macromolecules on membranes.