H
Helge Ewers
Researcher at Free University of Berlin
Publications - 87
Citations - 5053
Helge Ewers is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Microscopy & Super-resolution microscopy. The author has an hindex of 29, co-authored 75 publications receiving 4255 citations. Previous affiliations of Helge Ewers include École Polytechnique Fédérale de Lausanne & King's College London.
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Journal ArticleDOI
Live-Cell Super-resolution Reveals F-Actin and Plasma Membrane Dynamics at the T Cell Synapse.
George W. Ashdown,Garth L. Burn,David Williamson,Elvis Pandžić,Ruby Peters,Michael Holden,Helge Ewers,Lin Shao,Paul W. Wiseman,Dylan M. Owen +9 more
TL;DR: It is shown for the first time that not only does the dense actin cortex flow in a retrograde fashion toward the synapse center, but the plasma membrane itself shows similar behavior and is correlated with a third component, α-actinin, which upon CRISPR knockout led to reduced plasma membrane flow directionality despite increased actin flow velocity.
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Receptor concentration and diffusivity control multivalent binding of Sv40 to membrane bilayers.
Oliwia O.M. Szklarczyk,Nélido González-Segredo,Philipp Kukura,Ariella Oppenheim,Daniel Choquet,Vahid Sandoghdar,Ari Helenius,Ivo F. Sbalzarini,Helge Ewers +8 more
TL;DR: The results provide quantitative insight into the initial events of virus-host interaction at the nanoscopic level as receptor diffusion is essential for the establishment of stable binding over the physiological range of receptor concentrations and receptor concentration controls the mode of viral motion on the target membrane.
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Single Particle Tracking of α7 Nicotinic AChR in Hippocampal Neurons Reveals Regulated Confinement at Glutamatergic and GABAergic Perisynaptic Sites
TL;DR: The results suggest a possible role of α7-nAChR on interneurons for activating Ca2+-dependent signaling in the vicinity of GABAergic and glutamatergic synapses and cell surface dynamics is modulated by chronic changes in neuronal activity.
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The Bacterial SMC Complex Displays Two Distinct Modes of Interaction with the Chromosome
TL;DR: These findings reveal two distinct modes of interaction of SMC with the chromosome and indicate that limited diffusion within a confined space and transient arrest may be a general mechanism for positioning proteins within a chromosome and within a noncompartmentalized cell.
Journal ArticleDOI
A Simple Method for GFP- and RFP-based Dual Color Single-Molecule Localization Microscopy
Evgenia Platonova,Evgenia Platonova,Christian M. Winterflood,Christian M. Winterflood,Helge Ewers,Helge Ewers,Helge Ewers +6 more
TL;DR: This work provides a generic approach for high-quality simultaneous two-color single-molecule localization microscopy imaging of any combination of GFP- and RFP-tagged proteins with the use of nanobodies with only minimal technical requirements.